Application Notes

Articles

DAICEL’s CHIRALPAK® sub-2 µm columns yield sub 30-second chiral separations of Thalidomide and Naproxen under SFC conditions.

Ultra-fast Chiral SFC Separations

Multi-attribute analysis combines protein A affinity chromatography, SEC, and LC/MS in a 3D setup for assessment of features including mAb titer and size variants.


Multi-Attribute Analysis of Monoclonal Antibodies

Multi-attribute analysis combines protein A affinity chromatography, SEC, and LC/MS in a 3D setup for assessment of features including mAb titer and size variants.

This application note demonstrates the ability of Daicel’s CHIRALPAK® IA-3 to perform both chiral and achiral separations using SFC and Hydrobenzoin as a test compound.

SFC Achiral Separation Utilizing a Chiral Column

Daicel’s CHIRALPAK® IF proven to perform the difficult separations of cannabinoids Δ8-THC and Δ9-THC.

Separation of the Enantiomers of (+/-) Δ8-THC and (+/-) Δ9-THC

Amyloid β proteins are highly hydrophobic and can form aggregates. The analysis of 4 Aβ using YMC-Triart Bio C4 with larger pore and lower hydrophobicity is presented. 

Challenging analysis of Amyloid β proteins

Successful separations of the enantiomers of 3,3’-substituted BINOLs and their corresponding protected derivatives were obtained on the RegisPack® chiral stationary phase (CSP) from Regis Technologies, Inc.

Chiral Separations of 3,3’-Substituted BINOLs

A CHIRALPAK IG column (immobilized meta selector) was used to develop the enantioselective separation of methylclothiazide. Meta-substituted immobilized chiral selectors have been shown to have remarkable affinity for resolution of chiral compounds from different types of molecules. Available in 3 and 5 micron.

Separation of Methyclothiazide Using CHIRALPAK IG

A CHIRALPAK IG column (immobilized meta selector) was used to develop the enantioselective separation of methylclothiazide. Meta-substituted immobilized chiral selectors have been shown to have remarkable affinity for resolution of chiral compounds from different types of molecules.

Application Notes: Chiral