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Monday, February 28, 2022 at 11am EST | 8am PST | 4pm GMT **Monday, February 28, 2022 at 2pm EST | 11am PST | 7pm GMT**Tuesday, March 1, 2022 at 12pm JST | 11am CST | 3am GMT 
An emerging tool to tackle the complexity of biopharmaceutical analysis is multidimensional liquid chromatography (LC). This webcast will highlight the power of 2D-, 3D- and 4D-LC in hyphenation to mass spectrometry (MS) for the detailed characterization of protein biopharmaceuticals. 



In-depth Characterization of Biopharmaceuticals by Multi-dimensional LC/MS

 is Group Technical Director of Crawford Scientific Group and CHROMacademy. His background is in pharmaceutical R&D and polymer chemistry, but he has spent the past 20 years in training and consulting, working with Crawford Scientific Group clients to ensure they attain the very best analytical science possible. He has trained and consulted with thousands of analytical chemists globally and is passionate about professional development in separation science, developing CHROMacademy as a means to provide high-quality online education to analytical chemists. His current research interests include HPLC column selectivity codification, advanced automated sample preparation, and LC–MS and GC–MS for materials characterization, especially in the field of extractables and leachables analysis.

Articles

The improved performance of chromatographic detectors, most notably mass spectrometers, has enabled many advances in analytical science, however, one such advance may be given less prominence than perhaps it should.

The LCGC Blog: Automated Dynamic Liquid-Liquid Microextraction (DLLME) – Improve Sample Extraction, Buy Some Time, and Reduce Environmental Footprint

The 10 bad habits to avoid when producing HPLC mobile phases.

HPLC Mobile Phases – 10 bad habits to avoid

If there’s one mantra that’s essential for an LC (or GC)-MS operator it’s “contamination, contamination, contamination”. Keep contamination to a minimum and you’ll enjoy a reliable instrument; don’t take the necessary precautions and instead you’ll enjoy reaching for the vent switch and purchasing lots of spares.

10 Ways to Break Your LC-MS

Biopharmaceuticals offer great hope in treating medical conditions which are currently poorly served, at best, by traditional pharmaceuticals. It is estimated that there are over 400 biopharmaceuticals in clinical trials for in excess of 200 disease areas. The enhanced complexity and variability that comes from the size of biopharmaceuticals, allied with the intricacy of the production process, mean chromatography is employed to a much greater extent during production and release testing. The following article will introduce the fundamentals of biopharmaceutical analysis and cover the use of reversed phase HPLC in the analysis of biomolecules. A subsequent article will detail the application of HILIC, IEX, and SEC chromatography for the analysis if biomolecules.

Reversed Phase HPLC for the Analysis of Biomolecules

Whether your GC instrument has only been shut down for a couple of days or has been gathering dust in a corner for a year, follow CHROMacademy's quick checklist to increase performance and reliability.

GC Setup Checklist

This course has been designed for anyone who is either new to LC–MS, or who wishes to expand their current knowledge and understanding about the technique as a whole.

Fundamentals of LC–MS Chromatography - Video Training Course

CHROMacademy's Tutor: Scott Fletcher discusses whether HPLC method development has become a dying art.

Is the Art of HPLC Method Development Dead?

Selecting a gas chromatography (GC) column can be a daunting task. It may seem like there are a never-ending number of phase chemistries, or an inordinate number of column geometry options. However, when choosing a column for a new application (or to improve an existing one) there are some simple rules that can be followed.

How to Optimize the Key Variables in GC Analysis: GC Columns and Detectors

In this article our technical expert, Dr. Dawn Watson, will cover the polarity of the stationary phase, the column length, internal diameter, thickness of the stationary phase film and the required upper operating temperature.

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