April 25th 2024
A recent study used ultrahigh-pressure liquid chromatography (UHPLC) to identify traces of drugs on smartphones.
In the present study, a gradient reversed-phase high-performance liquid chromatography (RP-HPLC) method has been designed and validated to quantify ornidazole (OZ) in the marketed formulation (oral gel) with the application of QbD.
The 26th Norwegian Symposium on Chromatography
March 29th 2024The 26th Norwegian Symposium on Chromatography was held 21–23 January 2024. The symposium has strong traditions in the Norwegian separation science community, serving as a forum for excellent scientific talks, networking, and social events.
HPLC and ICP-MS/MS for Pesticide Detection in Fruits and Vegetables
March 5th 2024A recent study examined using high performance liquid chromatography (HPLC) with inductively coupled plasma–tandem mass spectrometry (ICP-MS) to detect ethylene-thiourea (ETU) and propylene-thiourea (PTU) in fruits and vegetables.
The Gradient Delay Volume, Part III: Practice – Effects on Throughput
March 1st 2024The concept of gradient delay volume (GDV) in liquid chromatography (LC) poses challenges for both beginners and experienced practitioners. The GDV, which affects the arrival time of mobile phase composition changes at the column inlet, can have a significant impact on method throughput, influencing the time required for mobile phase changes at both the beginning and end of the LC method. Different pump designs and column characteristics affect efficient use of the available analysis time, as well as overall throughput. Notably, achieving repeatable equilibration, rather than full equilibration of LC columns following mobile phase gradients, is often sufficient for many LC applications, which can also be leveraged to increase method throughput.
Pittcon 2024: Chromatographic Techniques Used to Detect PFAS
February 25th 2024On February 25, a Pittcon oral session, titled “Detection of PFAS and other Polyfluorinated Analytes,” took place at the San Diego Convention Center in San Diego, California. This session included six talks that covered a variety of analytical techniques currently being used in per- and polyfluoralkyl (PFAS) analysis.
New Study Reveals Enhanced Chiral Separation Method for Metconazole Fungicide
February 7th 2024Chromatographic techniques such as supercritical fluid chromatography and high-performance liquid chromatography was used to conduct chiral separation for metconazole, which is used as a fungicide to treat wheat diseases.
Separation of All Classes of Carbohydrates by HPAEC-PAD
High performance anion-exchange chromatography coupled with pulsed amperometric detection (HPAEC-PAD) is a potential method of choice for the analysis of carbohydrates.
Quantitative Determination of Four Lignans in Phyllanthus niruri L. by HPLC
February 1st 2024A simple analytical method using high performance liquid chromatography (HPLC) with ultraviolet (UV) detection was developed for the simultaneous determination of four main lignans (niranthin, nirtetralin B, hypophyllanthin, and phyltetralin) in Phyllanthus niruri L. plant samples from Guangxi province.
HPLC Methods with Different Detection Types Determine Whey Protein Content in Cheese
February 1st 2024High performance liquid chromatography (HPLC) was paired with both diode array and fluorescence detection (DAD and FLD, respectively) to measure Edam cheese for its total and acid-soluble whey content.
HPLC-DAD Measures Phytochemical, In Vitro, and In Silico Properties of Polygonum cognatum Meissn
January 31st 2024This study of the perennial herb also known as madimak (or Indian knotgrass) aimed to simultaneously determine phenolic compounds to gain more insights into their antioxidant or antimicrobial capabilities.
Synthesizing Synthetic Oligonucleotides: An Interview with the CEO of Oligo Factory
January 15th 2024LCGC and Spectroscopy Editor Patrick Lavery spoke with Oligo Factory CEO Chris Boggess about the company’s recently attained compliance with Good Manufacturing Practice (GMP) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Expert Working Group (Q7) guidance and its distinction from Research Use Only (RUO) and International Organization for Standardization (ISO) 13485 designations.
pH-Responsive Deep Eutectic Solvent Enables Accurate Bisphenol A Detection in Water
January 12th 2024This experiment introduced a deep eutectic solvent developed in conjunction with a pH-induced phase transition combined with high performance liquid chromatography (HPLC) for efficient trace determination of bisphenol A (BPA) in water samples.
New Analytical Platform for Traditional Chinese Medicine Component Analysis
January 5th 2024The research conducted by Jing Dong and team unveils a pioneering approach that not only unravels the complexities of Valeriana jatamansi, but also showcases the potential of advanced analytical techniques in comprehensively studying natural compounds.