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A group of scientists from Xi’an, China have created a new system for analyzing cell membranes based around HALO-tag technology.

Cell Membrane Chromatography Using HALO-tag Technology

A novel analytical method for the analysis of OLED materials using SFC is presented.

Analyzing the Light of the Future

 is the editor of “LC Troubleshooting”. Stoll is a professor and the co-chair of chemistry at Gustavus Adolphus College in St. Peter, Minnesota, USA. His primary research focus is on the development of 2D-LC for both targeted and untargeted analyses. He has authored or coauthored more than 75 peer-reviewed publications and four book chapters in separation science and more than 100 conference presentations. He is also a member of LCGC’s editorial advisory board. Direct correspondence to: 

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There are three important habits and practices that can improve the effectiveness and efficiency of any troubleshooter. 

Troubleshooting Odds and Ends to Close Out 2023: Questions from the Mailbag, and Second Opinions

We explore advancements in silica particles for liquid chromatography, focusing on the shift toward improved monodispersity and its impact on chromatographic parameters, efficiency, backpressure, and sensitivity in high-performance liquid chromatography (HPLC).

The Effect of Particle Monodispersity in HPLC Column Performance

The authors explore computer-aided workflows and machine learning, aimed at optimizing LC parameters, focusing on kinetic and thermodynamic aspects, and proposes closed-loop optimization strategies.

Approaches to Accelerate Liquid Chromatography Method Development in the Laboratory Using Chemometrics and Machine Learning

 has over 20 years of experience in the pharmaceutical industry, contributing to many product registrations. He is currently the Director of Regulatory CMC for Arcutis Biotherapeutics. Leon earned his PhD in analytical chemistry from the University of Delaware.

 is a principal of MWD Consulting, which provides training and consulting services in HPLC and UHPLC, method improvement, pharmaceutical analysis, and drug quality. He was formerly a Senior Scientist at Genentech, a Research Fellow at Purdue Pharma, and a Senior Staff Scientist at Applied Biosystems/PerkinElmer. He holds a PhD in Analytical Chemistry from City University of New York. He has more than 130 publications and a bestselling book in chromatography. He is an editorial advisory board member of LCGC North America and the Chinese American Chromatography Association. Direct correspondence to: 

This article provides a high-level overview of Current Good Manufacturing Practice (cGMP) regulations and related public quality standards.

Current Good Manufacturing Practice (cGMP): An Overview for Analytical Chemists

A novel study conducted at Nicolaus Copernicus University in Poland explores the potential of diatom-derived biosilica as a stationary phase in high-performance liquid chromatography (HPLC).

New Chromatographic Material Derived from Diatoms Shows Potential in High-Performance Liquid Chromatography

In a recent study conducted by two researchers from the CSIR-Indian Institute of Toxicology Research and the Academy of Scientific and Innovative Research, an analytical method was used to reveal coccidiostat residues in poultry.

Advancements in Analytical Techniques Reveal Coccidiostat Residues in Poultry

Two scientists from Baskent University in Ankara, Turkey analyzed multiple proteins in cream formulation using reverse-phase high-performance liquid chromatography.

Proteins in Cream Formulation Identified Via Reverse-Phase High-Performance Liquid Chromatography

Patrick Lavery is an Editor for the MJH Life Sciences brands LCGC and Spectroscopy, and their respective websites, 

. He previously spent nearly a decade as a news anchor, reporter, and producer at New Jersey 101.5 FM.

For the first time, inhibitors of a cyclooxygenase isoform were found in Allium ampeloprasum L., specifically the giant or “elephant” garlic grown in the Chiloé Archipelago.

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