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Kathryn Cash is an undergraduate researcher working with Dwight Stoll's research group at Gustavus Adolphus College, in St Peter, Minnesota.

Ezedin Seid is an undergraduate researcher working with Dwight Stoll's research group at Gustavus Adolphus College, in St Peter, Minnesota.

Tina Dahlseid is a Staff Scientist working with Dwight Stoll's research group at Gustavus Adolphus College in St Peter, Minnesota.

Articles

When can analyte retention deviate from what is expected or normal? We explain three subtle causes.

Essentials of LC Troubleshooting, Part II, Continued: More Misbehaving Retention Times

You're invited to publicize your 2022–2023 new product introductions in LCGC. Here's how to get your products included.

LCGC 2023 New Product Review – Call For Submissions

Tony Taylor is Group Technical Director of Crawford Scientific Group and CHROMacademy. His background is in pharmaceutical R&D and polymer chemistry, but he has spent the past 20 years in training and consulting, working with Crawford Scientific Group clients to ensure they attain the very best analytical science possible. He has trained and consulted with thousands of analytical chemists globally and is passionate about professional development in separation science, developing CHROMacademy as a means to provide high-quality online education to analytical chemists. His current research interests include HPLC column selectivity codification, advanced automated sample preparation, and LCâMS and GCâMS for materials characterization, especially in the field of extractables and leachables analysis.

The new General Chapter <621> does reflect the great work of the Pharmacopoeias in helping chromatographers to use more modern technology for their regulated methods, speeding up analysis, and reducing waste. The latest revision allows us to adjust column dimensions for gradient separations, which is a significant advance. Although these freedoms are welcomed, one must be very mindful of the requirements or limits of the allowable changes and the verification work that underpins our demonstration of equivalent performance of the adjusted method.

Allowable Changes to Chromatography Methods for HPLC – More Freedom for Chromatographers Granted by the Pharmacopeias?

Even relatively simple mixtures are not always easy to separate. What are the options for adjusting selectivity in reversed-phase LC separations?

What are Options to Improve My Separation? Part II: Likelihood of Separation, Adjusting Selectivity for Simple Mixtures

Peter Schoenmakers and Emanuela Gionfriddo are the winners of the 16th
annual LCGC Lifetime Achievement and Emerging Leader in Chromatography
Awards, respectively.

The 2023 Lifetime Achievement and Emerging Leader in Chromatography Awards

A column with chemically modified column hardware showed improvements in analytical performance for siRNA compared to a conventional stainless-steel column.

Analysis of siRNA with Denaturing and Non-Denaturing Ion-Pair Reversed-Phase Liquid Chromatography Methods

When considering different ways to improve an established LC method, it helps to start by reviewing some essential concepts.

What Are My Options to Improve My Separation? Part I: Foundational Concepts

Robots outperform humans in five areas, and thus can be particularly beneficial for performing sample preparation for HPLC.

Viewpoints: The Rise of Automation—Evolve or Die?

A harmonization of all conventional hold-up volume methods was successfully applied to RPLC, HILIC, AEX, and RP-AEX mixed-mode chromatography, regardless of the mobile phase.

Harmonization of Experimental Methods Used to Measure the True Hold-Up Volume of Liquid Chromatography Columns

An article from The Robot Report contrasted the performance of robots in industry against those of humans. The takeaways from the report are as follows.

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