 studied polymer chemistry in Mainz, Germany, and Amherst, Massachusetts, USA, and is head of the PSS contract analysis department. He is also responsible for instrument evaluation and for customized trainings. PSS is now part of Agilent.

Articles

This instalment of Tips & Tricks discusses the effect of column order on separation efficiency.

Tips & Tricks: Column Order in GPC/SEC

The benefits of a molar mass distribution over molar mass averages and the differences between the different representations of molar mass distributions are discussed.

Tips & Tricks: A Few Things Molar Mass Distributions Can (and Can’t) Tell

Did you know that applying the second derivative as a pretreatment to your
near-infrared spectral data can help resolve overlapped peaks?

Using Data Pretreatment to Improve Resolution

A key advantage of core-shell columns is that their performance can rival that of the traditional fully porous particle columns, but at somewhat larger particle sizes and at significantly lower backpressures.

Tips for Maximizing the Performance of Core-Shell Columns

Thermal desorption (TD) is a versatile preconcentration technique for gas chromatography (GC) that is used to analyze volatile and semi-volatile organic compounds in air, materials or liquids.

Five Frequently Asked Questions about Thermal Desorption

Combined with chromatography media, 96-well filter plates have emerged as an efficient tool for the fractionation of small-volume protein samples.

Efficient Protein Purification Strategies Using Multi-Well Filter Plates

Extra column volume is the volume in an HPLC system external to the column that contributes to the total peak volume, which will impact peak width, resolution, and overall efficiency.

Turn Down the Volume

A main goal of any U/HPLC analysis is to achieve the optimum sensitivity with the given instrumentation. Here are a few simple measures that can be easily implemented.


Simple Tips to Increase Sensitivity in U/HPLC Analysis

Things to Consider for Your Next GC–MS Instrument

With the introduction of the timsTOF platform, the next evolution in technology is achieved by adding an additional dimension of gas phase ion separation via the use of TIMS coupled to UHR-QTOF technology.