In this sixth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor compares the chromatographic properties of acetonitrile and methanol.

Ed Ahearne combined automation , machine learning and Bayesian optimization to speed up method development for siRNA medicines.

Data-independent acquisition (DIA) liquid chromatography-tandem mass spectrometry (LC–MS/MS) reveals shared and site-specific proteins across the thighbone.

Laura Righetti explains why quantification, not instrumentation, still keeps mass spectrometry imaging (MSI) out of routine food safety testing.

Large language models help chromatographers build LC pressure troubleshooting apps in hours.

Magnetic molecularly imprinted polymer extraction with liquid chromatography-high resolution mass spectrometry (LC–HRMS) finds patulin in store-bought juice.

Richard Bade and Malcolm McLeod explain to LCGC International how liquid chromatography-tandem mass spectrometry (LC-MS/MS) detects drug trends in wastewater.