Adapting HPLC to the Capillary Scale: Insights from Academia and Industry

Learn how scientists are adapting analytical high-performance liquid chromatography (HPLC) methods to the capillary scale—cutting solvent use, improving sensitivity, and adapting validated pharmaceutical monographs to the capillary scale without the need for revalidation.

Register Free: https://www.chromatographyonline.com/lcgc_w/capillary-scale

Event Overview:

Adapting high-performance liquid chromatography (HPLC) methods to the capillary scale opens new possibilities for pharmaceutical analysis and sustainability. This joint session with the University of Pavia and Axcend examines real-world method conversions that preserve performance while minimizing waste. Case studies include detection of a polar impurity in pediatric ibuprofen mini-tablets using a micro-HPLC-UV method, and a USP <621>-guided adaptation for hydrochlorothiazide demonstrating over 99% solvent reduction. Attendees will gain insight into practical guidelines, expected trade-offs, and data from both academic and regulated environments, offering a roadmap to adapting validated pharmaceutical monographs to the capillary scale without the need for revalidation.

Key Learning Objectives:

• Adapt pharmaceutical monographs to the capillary scale without revalidation
• Identify expected performance gains and trade-offs at low-flow rates
• Explore real-world data from academic and regulated environments

Who Should Attend:

• Chemists, analytical researchers, lab directors and managers, VPs and directors of QC/QA, lab owners, academics
• Next most relevant audience job positions

Speakers:

Sam Foster, Ph.D.
Scientist
Axcend

Dr. Samuel Foster completed his Ph.D. in Pharmaceutical Chemistry from Rowan University in 2025. His research has focused on the development and application of capillary scale liquid chromatography instrumentation. He currently works at Axcend as an application scientist focusing on the development of chromatographic workflows for a variety of analyte classes including oligonucleotides, monoclonal antibodies, and drugs of abuse.

Giorgio Marrubini, Ph.D.
Professor
University of Pavia

Giorgio Marrubini has been teaching Analytical Chemistry at the University of Pavia (2013-2024). He has been an adjunct professor of statistics applied to pharmaceutical sciences since 2023. His work focuses on analytical method development, with 35 years of expertise in HPLC, GC, and method validation in pharmaceutical analysis. He is the author of more than 80 publications as well as one book, and has been an invited speaker at national and international forums.

Register Free: https://www.chromatographyonline.com/lcgc_w/capillary-scale