Addressing the (EU) 2020/2184 Directive for the Performant Determination of Polar and Non-Polar Pesticide Panels Using a Common Reverse Phase LC-MS/MS Configuration

Chronic exposure to trace levels of pesticide residues in drinking water is primarily linked to serious, long-term health effects such as cancer, neurological disorders, and endocrine disruption.

We describe two drinking water LC/MS workflows to cover, i) panels of classic pesticides, and ii) underivatized polar pesticides, both using a standard C18 reverse phase chromatography set up. The classic pesticide method also includes the determination of the microcystin-LR toxin which poses a risk of liver damage (hepatotoxicity) and is classified as a possible human carcinogen. The polar pesticides workflow requires minimal sample preparation without the need for sample derivatization andboth workflows are designed to meet both EU and UK water testing requirements using the same chromatography and MS detection system.