Automated Sample Preparation for Oligonucleotide Bioanalysis Using Magnetic SPE

Join us to learn how magnetic bead-based sample preparation can simplify oligonucleotide bioanalysis by reducing hands-on time, increasing throughput, and delivering reproducible results.

Register Free: https://www.chromatographyonline.com/lcgc_w/magnetic

Event Overview:

Conventional oligonucleotide sample preparation methods, such as LLE and SPE, can be labor-intensive, time-consuming, and difficult to scale for high-throughput bioanalysis. Magnetic solid-phase extraction (MSPE) using weak anion-exchange chemistry offers a streamlined approach for extracting oligonucleotides from plasma and tissue matrices. This virtual event presents application examples showing how MSPE can reduce hands-on time, improve reproducibility, and support LC-MS/MS workflows. Attendees will gain practical insights into workflow optimization for faster, cleaner, and more consistent oligonucleotide bioanalysis.

Key Learning Objectives

• Understand MSPE principles and the sample preparation workflow.
• Explore ASO and siRNA extraction from plasma and tissue matrices.
• Learn practical strategies for optimizing MSPE workflows.

Who Should Attend

• CRO and Pharma Scientists in DMPK, Bioanalytical Sciences, Analytical Development, and Quality Control (CMC) working with oligonucleotide using LC/MS.
• Biotech and academic researchers working on oligonucleotide therapeutics and using LC-MS/MS for bioanalysis.

Speakers

Jenny Zhang, Ph.D.
General Manager
Unified Separation Technologies

Jenny Zhang, Ph.D., is General Manager of Unified Separation Technologies (UST), where she leads business development, marketing, and commercialization of chromatography process media and analytical products. She has more than 17 years of experience in the life sciences industry. Since joining UST in 2024, she has focused on advancing magnetic SPE and automated sample-preparation solutions for bioanalysis and proteomics workflows.

Michael Johnson
Associate Director
BioQual Solutions Inc.

Michael Johnson, MS, is a Director at BioQual Solutions, a San Diego bioanalytical CRO specializing in LC-MS. He leads GLP and non-GLP assay development for small molecules, peptides, and oligonucleotides. With 17+ years of industry experience at Takeda, Ignyta, Ionis, and BioQual, he focuses on assay development and evaluating new technologies to simplify bioanalytical workflows.

Nuozhou Chen, Ph.D.
Scientist
Resolian

Nuozhou Chen, Ph.D., is an LC-MS Scientist at Resolian specializing in bioanalytical method development for small and large molecules. He earned his Ph.D. in Biomedical Engineering from Rutgers University and previously worked in the DMPK group at GSK. With over three years of industry experience, he has developed, validated, and applied LC-MS/MS assays in regulated and non-regulated settings to support drug discovery and development.

Register Free: https://www.chromatographyonline.com/lcgc_w/magnetic