Gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–tandem mass spectrometry (LC-MS/MS) link tobacco leaf chemistry to cigar taste and burning.
Feature|Videos|November 12, 2025
Calibrate With Confidence: From Trace Gas to Percent-Level Gases
Author(s)Danet Vrazel, KIN-TEK Analytical, Inc.
Permeation tubes and systems that dynamically generate fresh, NIST-traceable gas standards offer significant benefits for calibration and R&D applications, particularly when working with trace concentrations in laboratory or industrial settings.
Permeation tube technology offers a precise, flexible alternative to gas cylinders for generating NIST-traceable standards on demand. Danet Vrazel of KIN-TEK Analytical, Inc. outlines how this approach streamlines calibration for labs and industrial sites alike, covering trace-level work from ppm to ppt, field-ready systems for process GCs, and when to shift to percent-level gases. Additionally, she covers how automation and data logging provide consistency and confidence for every calibration.
Key Learning Objectives:
- Recognize the advantages of using permeation tubes for trace gas calibration.
- Understand the benefits of an automated permeation tube system with data logging capabilities.
- Learn how to move beyond trace concentrations to percent-level gases for calibration.
Related to this article
The model context protocol (MCP) layer lets AI run mzmine mass spectrometry workflows; data stays local.
Ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) reveals a chemical imbalance behind alcohol-positive milk.
"Perspectives in HPLC" examines 5 long-held HPLC "rules" (mobile phase filtration, routine buffer use, avoiding pH near an analyte's pKa, defaulting to 4.6-mm columns, and relying on AI for early method development), showing with experimental evidence that each is conditional rather than universally true in modern small-molecule drug testing.
In this ninth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explores the reasons why mobile phase filtration is not needed.
A review of affinity chromatography methods for biopharmaceutical analysis.
Ultrahigh-performance liquid chromatography–ion mobility–quadrupole time-of-flight mass spectrometry (UHPLC–IM–QTOF MS) reveals seasonal chemical fingerprints in Scottish honey.
Markes International’s vacuum-assisted HiSorb extends analyte coverage for gas chromatography.
Trending on LCGC International
1
Debunking Myths and Half-Truths in HPLC and Pharmaceutical Analysis
2
From PFAS to Pyrolysis Oil: Highlights from GCC 2026
3
Affinity Chromatography for Biopharmaceutical Analysis: A Mini-Review of History, Principles, and Potential Applications
4
Peaks & Pioneers: Amandaa Brewer on Chromatography’s Coming Expertise Gap
5