Gas chromatography-mass spectrometry (GC-MS) coupled with headspace solid-phase microextraction )HS-SPME) links cocoa variety to chocolate aroma and flavor profiles.
News|Articles|September 22, 2026
Characterizing LNPs: Meeting Regulatory Expectations With FFF-MALS
Author(s)Waters Corporation
This executive summary examines how field-flow fractionation coupled with multi-angle light scattering (FFF-MALS) characterizes lipid nanoparticles (LNPs) as regulatory expectations from FDA, EMA, and USP converge on a shared set of critical quality attributes. It walks through how FFF-MALS resolves particle size, molar mass, and payload distribution in a single non-destructive run, and includes a case study comparing two authorized mRNA vaccines. Readers will see how size-resolved analysis uncovered differences in payload distribution that bulk-average methods missed.
Related to this article
Emma Macturk from LECO Corporation explains which forensic applications benefit from GC×GC’s greater peak capacity, and when the additional separation power may only provide limited benefits.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identifies blood metabolite patterns tied to children's diets.
Kirstine Nielsen of Aarhus University (Denmark) discusses how targeted metabolomics ratios helped build a robust bloodstain time-since-deposition tool.
This new liquid chromatography-tandem mass spectrometry- quadrupole ion trap (LC-MS/MS-QTRAP) method identifies rat poisons in cat forensic cases.
Gérard Hopfgartner explains how atmospheric pressure photoionization can generate radical cations in LC–MS, unlocking EI-style spectra and NIST's spectral library.
Isabelle Kohler traces her unplanned path from pharmacy to bioanalysis, and why the same career struggles cut across gender lines in her PhD coaching.
LCGC International spoke to Akina Nara of Japan’s Tohoku Medical and Pharmaceutical University about a new study which links a blood compound to how long a body has been dead.