This month's installment of "CE Currents" deals with problems that may arise when using capillary electrophoresis for unattended, long-term operation. The guest authors look at issues such as sample carryover, evaporation effects, capillary conditioning, capillary surface changes, buffer handling, capillary breakage, and detector lamp deterioration. They provide several technical recommendations for stabilizing the electrophoretic system and increasing reproducibility.

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