PRP-C18 for Oligonucleotide Purifications

March 1, 2021

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The Hamilton PRP-C18 is a next-generation polymeric column based on porous C18-functionalized PS-DVB that exhibits excellent chemical and thermal stability. Click the title or image for more information.

The Hamilton PRP-C18 is a next-generation polymeric column based on porous C18-functionalized PS-DVB that exhibits excellent chemical and thermal stability. Unlike other polymer columns, the octadecylated surface modification imparts superior mass transfer kinetics for high efficiency separations and excellent mechanical stability.

The flexibility to employ elevated temperatures (up to 100 °C) and alkaline pH are important tools in oligonucleotide purifications. The PRP-C18 does not dissolve, phase-strip, or bleed, even under the most extreme operating conditions, unlocking the power of superior resolution between long oligos and their failure sequences. Because the PRP-C18 stationary phase is devoid of silanols found in silica-C18 columns, peak tailing, poor recovery, and carry-over problems are completely eliminated, offering significant value.

Hamilton Company

Reno, NV

www.hamiltoncompany.com/oligo