Sample preparation is the most crucial step for the development of an analytical method. The main purpose of sample preparation is the extraction and preconcentration of the target analytes, as well as the removal of the matrix interferences, before their separation and determination. It is the most time consuming step that should be deliberately optimized to enhance extraction selectivity and detection capability. LLE and SPE, along with their variations, are usually applied for sample extraction and cleanup. MIPs can replace conventional sorbent materials in sample preparation techniques such as SPE, SMPE, and MSPD, offering increased selectivity over the target analytes. Attention is given in MISPE, which is mostly used to study MIP applications, as well as a commercially available technique.
Molecularly imprinted polymers can replace conventional sorbent materials in sample preparation techniques such as solid-phase extraction (SPE), solid-phase microextraction (SMPE), and matrix solid-phase dispersion (MSPD), offering increased selectivity over the target analytes.