The Column-05-24-2016

The Column

LGC Awarded Ethical Status

May 25, 2016

News

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LGC Standards has been awarded a Responsible Sourcing status by Sedex for its Standards division in Germany. A non-profit membership organization, Sedex is dedicated to improving responsible and ethical business practices in global supply chains.

Past, Present, Future

May 24, 2016

Cover Story

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To mark the Chromatographic Society’s 60th birthday, The Column interviewed the current President of The Chromatographic Society, Dr. Paul Ferguson, and Associate Principal Scientist for Separation Science at AstraZeneca, Macclesfield, UK, on the past, present, and future of the Chromatographic Society - and separation science.

Vol 12 No 9 The Column May 24, 2016 Europe and Asia PDF

May 24, 2016

Issue PDF

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Click the title above to open The Column May 24, 2016 Europe & Asia issue, Volume 12, Number 9, in an interactive PDF format.

Vol 12 No 9 The Column May 24, 2016 North American PDF

May 24, 2016

Issue PDF

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Click the title above to open The Column May 24, 2016 North American issue, Volume 12, Number 9, in an interactive PDF format.

Trends and Challenges for Bioanalysis and Characterization of Small and Large Molecule Drugs

April 26, 2016

Features

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Structural, bioanalytical, characterization, and quality control studies are critical for successful drug development. These studies must be as accurate, sensitive, and selective as possible, and liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) has been the technique of choice for many areas of small molecule analysis for the past 30 years. During that time, rapid improvements in analytical technologies have supported the development of more sensitive and robust methods. However, the pharma and biopharma industry continues to need more powerful instruments and more diverse methods, particularly as therapeutics have expanded to include large molecules. This work follows on from an earlier article that explored the limitations of LC–MS–MS for bioanalysis of biologics. This article considers some of the current issues for analysis of small and large molecules, and emerging trends in method development.