The Column-07-07-2014

Waters Corporation and PSS GmbH have announced the return of the International GPC/SEC Symposium to be held at The Westin Grand Frankfurt Hotel in Frankfurt, Germany, on 30 September–2 October 2014.

The Column
Features

July 07, 2014

Ion chromatography (IC) is often used for the chromatographic separation of a wide range of compounds. In a laboratory that already uses HPLC or UHPLC, will the implementation of IC be expensive in terms of instrumentation or resources?The Column spoke to Ade Kujore of Cecil Instruments Limited to find out.

Thirty percent of approved drugs will be based on recombinant monoclonal antibody (rMab) drugs over the next 10 years. Glycosylation, the convalent addition of carbohydrates to proteins, can influence properties of rMab drugs and has to be closely monitored during drug development and production. Scientists from the University of California (California, USA) have developed a new liquid chromatography–mass spectrometry (LC–MS) N-glycan library based on eight commercially available recombinant monoclonal antibodies, for the rapid identification of glycosylated structures.

Scientists from Emory University (Georgia, USA) have developed a new solid–phase extraction (SPE) method to isolate four insecticide degradates from baby food for analysis by high performance liquid chromatography tandem mass spectrometry (HPLC–MS–MS). The paper published in the Journal of Agricultural and Food Chemistry describes how the method can be applied to differentiate between exposure to insecticides or preformed degradates.

The Column

The first commercial capillary ion chromatography (IC) systems became available in 2010, but uptake of the technique has been slow even though it has many benefits. Here, we review those benefits and present selected application areas where it is proving especially useful.

The study of sewage using chromatographic techniques is a rapidly expanding area that can provide insights into the consumption of illicit drugs. Measuring illicit drug concentrations can provide authorities with a close to real time identification of consumption trends and rates in specific geographical areas.

This article presents a method that combines combustion digestion and ion chromatography into a single analysis (combustion ion chromatography [CIC]) making it possible to detect halogens and sulphur in complex matrices. The method is suitable for use in a wide range of application areas.

An excerpt from LCGC's e-learning tutorial on HPLC problems at CHROMacademy.com.

Click the title above to open The Column July 07, 2014 North American issue, Volume 10, Number 12, in an interactive PDF format.

Click the title above to open The Column July 07, 2014 Europe & Asia issue, Volume 10, Number 12, in an interactive PDF format.