The Column-07-07-2014

The Column

Ion Chromatography in Practice

July 07, 2014

Features

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Ion chromatography (IC) is often used for the chromatographic separation of a wide range of compounds. In a laboratory that already uses HPLC or UHPLC, will the implementation of IC be expensive in terms of instrumentation or resources?The Column spoke to Ade Kujore of Cecil Instruments Limited to find out.

N–glycan Biopharmaceutical Reference Library

July 07, 2014

News

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Thirty percent of approved drugs will be based on recombinant monoclonal antibody (rMab) drugs over the next 10 years. Glycosylation, the convalent addition of carbohydrates to proteins, can influence properties of rMab drugs and has to be closely monitored during drug development and production. Scientists from the University of California (California, USA) have developed a new liquid chromatography–mass spectrometry (LC–MS) N-glycan library based on eight commercially available recombinant monoclonal antibodies, for the rapid identification of glycosylated structures.

HPLC–MS–MS Detects Insecticide Degradates in Baby Food

July 07, 2014

News

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Scientists from Emory University (Georgia, USA) have developed a new solid–phase extraction (SPE) method to isolate four insecticide degradates from baby food for analysis by high performance liquid chromatography tandem mass spectrometry (HPLC–MS–MS). The paper published in the Journal of Agricultural and Food Chemistry describes how the method can be applied to differentiate between exposure to insecticides or preformed degradates.

Capillary Ion Chromatography Gains Momentum

July 07, 2014

Cover Story

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The first commercial capillary ion chromatography (IC) systems became available in 2010, but uptake of the technique has been slow even though it has many benefits. Here, we review those benefits and present selected application areas where it is proving especially useful.

Analysis of Wastewater in New York State Indicates Illicit Drug Consumption

July 07, 2014

News

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The study of sewage using chromatographic techniques is a rapidly expanding area that can provide insights into the consumption of illicit drugs. Measuring illicit drug concentrations can provide authorities with a close to real time identification of consumption trends and rates in specific geographical areas.

Determination of Halogens and Sulphur in Complex Matrices

July 07, 2014

Features

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This article presents a method that combines combustion digestion and ion chromatography into a single analysis (combustion ion chromatography [CIC]) making it possible to detect halogens and sulphur in complex matrices. The method is suitable for use in a wide range of application areas.

Vol 10 No 12 The Column July 07, 2014 North American PDF

July 07, 2014

Issue PDF

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Click the title above to open The Column July 07, 2014 North American issue, Volume 10, Number 12, in an interactive PDF format.

Vol 10 No 12 The Column July 07, 2014 Europe and Asia PDF

July 07, 2014

Issue PDF

12

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Click the title above to open The Column July 07, 2014 Europe & Asia issue, Volume 10, Number 12, in an interactive PDF format.