Alasdair Matheson

A new “one-shot” strategy for preparative chiral supercritical fluid chromatography (SFC) offers fast and effective approach to obtain and characterize individual enantiomers.

SFC delivers measurable cycle-time and solvent-use gains beyond chiral work, spanning biopharma and anti-doping applications, experts say.

Kevin Schug explains how surrogate optimization streamlines SFE–SFC–MS method development, achieving R² values up to 0.97 while boosting sensitivity by 15%

In preparative chiral supercritical fluid chromatography (SFC), adding 2.5–5% water cuts retention times and narrows collection windows, boosting throughput.

Caroline West on supercritical fluid chromatography's advances, pharmaceutical applications, and sustainability.

At ISC 2026, a tailored C4 stationary phase resolved over 30 of 64 possible siRNA diastereomers, aiding characterization of oligonucleotide conjugates.

At ISC 2026, a 20-minute IP-RPLC–UV assay distinguished mRNA capping variants without mass spectrometry, matching a UHPLC–MS reference method.

At ISC 2026, separation science advances included a MEMS gas chromatography column for space missions that raised measured efficiency by up to 74%

At ISC 2026, food and natural matrix research showed shea kernel processing history shapes chemistry more than geographic origin, aiding quality control.

Summary: A preview of 2026 separation science trends, from PFAS and SFC to metabolomics, next-generation HPLC columns, oligonucleotides, and ADC analysis.

Hans-Gerd Janssen explores the industry's shift from fully integrated online systems to at-line approaches.

Gaëlle Spileers from the Separation Science Group in the Department of Organic and Macromolecular Chemistry at Ghent University, Belgium discusses developments in high performance liquid chromatography (HPLC–XRF) for the analysis of brominated flame retardants and other pollutants.

Gaëlle Spileers from the Separation Science Group in the Department of Organic and Macromolecular Chemistry at Ghent University, Belgium discusses developments in high performance liquid chromatography (HPLC–XRF) for the analysis of brominated flame retardants and other pollutants.

Frederic Lynen from the Separation Science Group in the Department of Organic and Macromolecular Chemistry at Ghent University, Belgium discusses why he worked with Gaëlle Spileers to develop a high performance liquid chromatography X-ray fluorescence (HPLC–XRF) technique to analyze brominated flame retardants and other pollutants.

Melissa Dunkle, senior research scientist at Dow Benelux BV, The Netherlands, explores practical aspects of using multidimensional pyrolysis gas chromatography (Pyr-GCxGC) to investigate fluoropolymer degradation.

Daniel Vik from Amgen Research Copenhagen, Denmark discusses the motivation behind applying machine learning to chromatographic retention time prediction and its growing importance in modern pharmaceutical research. He shares insights into the challenges of developing robust predictive models, their role in supporting high-throughput drug discovery workflows, and the potential of artificial intelligence to make analytical chemistry more efficient and scalable.

Melissa Dunkle, senior research scientist at Dow Benelux BV, The Netherlands, discusses the revival of interest in pyrolysis gas chromatography.

Andrea Hochegger from Graz University of Technology, Austria describes the benefits that comprehensive two-dimensional GC (GC×GC–MS) offers over conventional GC–MS to resolve complex mixtures from recycled packaging materials.

Lapo Renai from the Van 't Hoff Institute for Molecular Sciences, The Netherlands discusses a novel prediction model for estimating chemical space coverage for non-targeted LC–ESI–HRMS workflows.

James Grinias from Rowan University, New Jersey, USA, discusses sustainability and modern capillary LC systems.

Jim Grinias from Rowan University, NJ, USA highlights advances in miniaturized capillary LC–MS that simplify system setup and improve ease of use. He also discusses low-flow challenges and how integrated components can enhance performance and reproducibility.

Jonathan Maurer from the University of Geneva, Switzerland describes using HILIC for oligonucleotide analysis in practice and the role of HILIC for other biopharmaceutical applications.

Jonathan Maurer from the University of Geneva, Switzerland describes some of the challenges and misconceptions surrounding hydrophilic interaction chromatography (HILIC) and oligonucleotide analysis.

Nikoline Juul Nielsen from the University of Copenhagen, Denmark explores deprotomer formation for accurate CCS prediction and metabolite identification and the potential of implementing these workflows for routine use.

LCGC International spoke with Nikoline Juul Nielsen from the University of Copenhagen, Denmark on the benefits of RPLC×HILIC–cIMS for data-independent profiling of phenolic constituents in plant extracts. In this episode she explores practical aspects of cIMS and the potential for routine analysis.

LCGC International spoke with Nikoline Juul Nielsen from the University of Copenhagen, Denmark about the benefits of comprehensive two-dimensional liquid chromatography (RPLC×HILIC)—cyclic ion mobility-time-of-flight mass spectrometry (cIMS) for analyzing plant extracts.

Giorgia Purcaro from the University of Liege (Belgium) discusses a laboratory technique for more accurately detecting harmful oil contaminants in edible oils than the current official method.

During her PhD at BOKU University Vienna, Lidija Kenjerić developed a multi-class UHPLC–MS/MS quantitative method covering 931 mycotoxins and secondary metabolites within an 11-min runtime, providing a scalable solution for routine testing, regulatory, and emergency response.

Stefan Van Leuwen and Jana Pulkrabova—co-chairs of RAFA 2026—elaborate on why separation scientists involved in food analysis should attend RAFA 2026, which takes place at the Clarion Congress Hotel Prague, Prague, Czech Republic, from November 3–6, 2026.

Hans-Gerd Janssen explores the reality of real-time analytical measurement.