Articles by Alasdair Matheson
Daniel Vik from Amgen Research Copenhagen, Denmark discusses the motivation behind applying machine learning to chromatographic retention time prediction and its growing importance in modern pharmaceutical research. He shares insights into the challenges of developing robust predictive models, their role in supporting high-throughput drug discovery workflows, and the potential of artificial intelligence to make analytical chemistry more efficient and scalable.
Melissa Dunkle, senior research scientist at Dow Benelux BV, The Netherlands, discusses the revival of interest in pyrolysis gas chromatography.
Andrea Hochegger from Graz University of Technology, Austria describes the benefits that comprehensive two-dimensional GC (GC×GC–MS) offers over conventional GC–MS to resolve complex mixtures from recycled packaging materials.
Lapo Renai from the Van 't Hoff Institute for Molecular Sciences, The Netherlands discusses a novel prediction model for estimating chemical space coverage for non-targeted LC–ESI–HRMS workflows.
James Grinias from Rowan University, New Jersey, USA, discusses sustainability and modern capillary LC systems.
Jim Grinias from Rowan University, NJ, USA highlights advances in miniaturized capillary LC–MS that simplify system setup and improve ease of use. He also discusses low-flow challenges and how integrated components can enhance performance and reproducibility.
Jonathan Maurer from the University of Geneva, Switzerland describes using HILIC for oligonucleotide analysis in practice and the role of HILIC for other biopharmaceutical applications.
Jonathan Maurer from the University of Geneva, Switzerland describes some of the challenges and misconceptions surrounding hydrophilic interaction chromatography (HILIC) and oligonucleotide analysis.
Nikoline Juul Nielsen from the University of Copenhagen, Denmark explores deprotomer formation for accurate CCS prediction and metabolite identification and the potential of implementing these workflows for routine use.
LCGC International spoke with Nikoline Juul Nielsen from the University of Copenhagen, Denmark on the benefits of RPLC×HILIC–cIMS for data-independent profiling of phenolic constituents in plant extracts. In this episode she explores practical aspects of cIMS and the potential for routine analysis.
LCGC International spoke with Nikoline Juul Nielsen from the University of Copenhagen, Denmark about the benefits of comprehensive two-dimensional liquid chromatography (RPLC×HILIC)—cyclic ion mobility-time-of-flight mass spectrometry (cIMS) for analyzing plant extracts.
Giorgia Purcaro from the University of Liege (Belgium) discusses a laboratory technique for more accurately detecting harmful oil contaminants in edible oils than the current official method.
During her PhD at BOKU University Vienna, Lidija Kenjerić developed a multi-class UHPLC–MS/MS quantitative method covering 931 mycotoxins and secondary metabolites within an 11-min runtime, providing a scalable solution for routine testing, regulatory, and emergency response.
Stefan Van Leuwen and Jana Pulkrabova—co-chairs of RAFA 2026—elaborate on why separation scientists involved in food analysis should attend RAFA 2026, which takes place at the Clarion Congress Hotel Prague, Prague, Czech Republic, from November 3–6, 2026.
Hans-Gerd Janssen explores the reality of real-time analytical measurement.
Hans-Gerd Janssen explores the industry's shift from fully integrated online systems to at-line approaches.
30% of GC–MS peak annotations and integrations have been observed to be inaccurate. Hans-Gerd Janssen highlights some of the most promising strategies to improve data reliability and reduce errors.
Hans-Gerd Jansses discusses problems associated with LC–MS peptide identification data with sensory perception and the identification of specific tastants for food analysis.
Hans-Gerd Janssen highlights the important innovations and challenges remaining using hyphenated spearation science techniques in food analysis.
Bo Zhang from Xiamen University, Xiamen, China discusses his upcoming lecture at HPLC 2026 that reveals a new way to design and manufacture chromatographic materials. This new approach indicates that chromatographic media can be intentionally engineered rather than developed through “trial-and-error” synthesis. By independently controlling particle morphology and pore architecture, separation materials can be rationally designed and optimized for specific applications
A session on Thursday 29 May 2026 at HTC-19 in Leuven, Belgium called The Power of The Hyphen brought together five presentations exploring the application of multidimensional and coupled chromatographic methods to complex analytical challenges in food and beverage, petroleum, environmental, and pharmaceutical applications.
James P. Grinias from Rowan University, Glassboro, New Jersey, United States, is the winner of the 2026 HTC Innovation Award, which was presented at the Hyphenated Techniques and Separations Technology (HTC-19) conference in Leuven, Belgium, on Friday May 29, 2026. The award is co-sponsored by the HTC conference and LCGC International.
The first session at HTC-19 in Leuven on Wednesday 27 May 2026 kicked off with an inspiring tryptch of speakers —Caroline West, Leon Barron, and Jackie Mosely—exploring innovative aspects of modern hyphenated chromatography.
An illuminating session called AI and Modelling on Wednesday 27 May 2026 at HTC-19 in Leven, Belgium focused on automated and computational approaches to LC method development, with five presentations spanning Bayesian optimization, hybrid retention modelling, QSAR-based retention prediction, graph-theoretic peak alignment, and functional data analysis
Element Lab Solutions was officially rebranded as Crawford Scientific on 1st May 2026.
Alba Rodriguez Otero combined liquid chromatography with high resolution mass spectrometry (LC–HRMS) with hierarchical cluster analysis to interpret the non-targeted features to assess this novel workflow to asses novel materials for wastewater treatment.
André Striegel gives an update on the evolution of macromolecular separation science and the rationale behind recently publishing his aptly named reference text book: "Macromolecular Separation Science".
With open access to GreenSOL, Elia Psillakis describes how laboratories are adopting it in practice.
The first assessment of deuterated solvents reveals significant, often overlooked environmental burdens tied to essential analytical reagents.
Dr Victoria Samanidou from the School of Chemistry at the Aristotle University of Thessaloniki, Greece, gives a detailed overview of applying green metrics tools in the "real world."
