Determination of Acrylamide in Water by Liquid Chromatography Coupled to Tandem Mass Spectrometry
June 01, 2014
An analytical method based on liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) has been developed for the determination of acrylamide in water. To obtain clean extracts and low detection limits, an activated carbon cartridge was investigated for use in solid-phase extraction (SPE), and extraction conditions such as desorption solvent and elution volume were optimized by a series of experiments. High recoveries (99.1–99.8%) were obtained using the activated carbon solid-phase extraction cartridges with methanol as the eluent. This method could be applied to the quantification of acrylamide in environmental water samples.