LCGC Europe-09-01-2016

LCGC Europe

Pyrolysis–Liquid Chromatography for the Analysis of Acrylic Resins

September 01, 2016

Features

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The determination of the chemical composition distribution of acrylic resins is not straightforward. Pyrolysis–gas chromatography (py-GC) analyses of acrylic resins can yield problems in the recovery of the hydroxyl and acid functional fragments that form. To overcome these problems pyrolysis–liquid chromatography (py-LC) can be performed. This article describes how the validation and quantification of hydroxyl acrylate-, hydroxyl methacrylate-, hydroxyl propylacrylate-, and hydroxyl propylmethacrylate resins by py-LC is performed. Furthermore, off-line size-exclusion chromatography (SEC) coupled to py-LC is performed to determine the chemical composition distribution over the molecular weight distribution of a core–shell waterborne acrylic resin.

Highlights from HPLC 2016

September 01, 2016

Column Watch

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The 44th International Symposium of High Performance Liquid Phase Separations and Related Techniques (HPLC 2016), chaired by Professor Robert Kennedy, was held 19–24 June in San Francisco, California, USA, at the Marriott San Francisco Marquis. This instalment of “Column Watch” covers some of the highlights observed at the symposium, including stationary-phase developments, particle technology, and areas of growing application of high performance liquid chromatography (HPLC). In addition, trends and perspectives on future developments in HPLC noted from the conference are presented.

Paper, Paper Everywhere but None of it Controlled?

September 01, 2016

Questions of Quality

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One of the common threads in the six data integrity guidance documents published to date is the need to control any blank forms used in regulated GXP laboratories. This month’s “Questions of Quality” is focused on how to interpret the regulator’s requirements for this topic. We also pose the question: Is paper the best way to record regulated data?

A Universal Reversed‑Phase HPLC Method for Pharmaceutical Analysis

September 01, 2016

Perspectives in Modern HPLC

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A universal generic high performance liquid chromatography (HPLC) or ultrahigh-pressure liquid chromatography (UHPLC) method with a primary modern column that works well for most drug analyses in a few minutes would be an attractive idea for many laboratories. With advances in column technologies, this ideal scenario is becoming more realistic, as demonstrated in the proposed 2-min generic method shown here. In addition, rationales for the selection of column and operating conditions are discussed, together with ways to extend this generic method as a starting point for stability-indicating applications by simple adjustments of gradient time and range.

Vol 29 No 9 LCGC Europe September 2016 Regular Issue PDF

September 01, 2016

Issue PDF

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Click the title above to open the LCGC Europe September 2016 regular issue, Vol 29, No 9, in an interactive PDF format.