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HPLC
Ion Chromatography
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Process Analytical Technology (PAT)
Quality Control/Quality Assurance (QA/QC)
Quality by Design (QbD)
Regulatory Standards, GLP and GMP Compliance
Sample Preparation
Size-Exclusion Chromatography (SEC)
Solid-Phase Extraction (SPE)
Supercritical Fluid Chromatography (SFC)
Supercritical Fluid Extraction (SFC)
The Next Generation
Thin Layer Chromatography
Trends
UHPLC
Web of Science
IS1
  • Applied Clinical Trials

  • BioPharm International

  • Cannabis Science and Technology

  • Chromatography Online

  • Nutritional Outlook

  • Pharmaceutical Commerce

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LCGC Europe-11-01-2009

home / journals / lcgc-europe / lcgc-europe-11-01-2009-0

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A Novel Sample Preperation Approach to Increase the Throughput of Pesticide Analysis by LC–MS–MS

November 1st 2009
ArticleRegular article

The high-throughput analysis of pesticides in raw agricultural commodities has been hindered by the slow and laborious sample preparation stages. Using traditional clean-up procedures, as many as 20 steps are required to get the sample in a convenient form for analysis, which typically limits sample throughput to eight samples per day. This study evaluates a new approach using a novel laboratory mill and pulverizer to extract various pesticide residues from different kinds of plant materials and to identify and quantify the active ingredients by liquid chromatography tandem mass spectrometry (LC–MS–MS). It shows that by automating the procedure, the number of clean-up steps can be reduced significantly, which increases sample throughput over traditional approaches.


i1-641811-1408638942792.jpg

Commercialization of LC–MS: The Second Decade

Michael P. Balogh
November 1st 2009
ArticleMS - The Practical Art

"In retrospect, we sometimes see the successful return of an earlier idea on the back of great advances in technology."


i1-641808-1408638953438.jpg

Method or System?

John W. Dolan
November 1st 2009
ArticleLC Troubleshooting

Where to place the blame when something goes wrong.

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