LCGC North America-01-01-2001

January 01, 2001

This first installment of a two-part series outlines the principles and approaches to indirect detection.

January 01, 2001

The FDA recently updated its 1987 guidelines for submitting samples and analytical data for method validation — a document that affects all analytical chemists working in the pharmacrutical industry. This article highlights the agency's recommendations of how to report and validate analytical data in all new drug applications.

January 01, 2001

In this month's installment of "LC Troubleshooting," John Dolan focuses on late-eluted peaks.

January 01, 2001

Norberto Guzman and Ron Majors look at three areas in which progress has been made in improving concentration limits of detection for CE and CE microchip techniques: preconcentration methods, detector enhancements, and derivatization methods to improve separation selectivity and to enhance detection.

January 01, 2001

Leslie Ettre outlines the transition from metal tubes to glass and finally to fused-silica tubing and discusses improvements in stationary-phase technology. He also mentions some trends for further improvement of capillary column GC.

January 01, 2001

The authors compare fast LC}MS with a flow injection analysis}MS method for effective quantitation in the high-throughput environment of today's drug discovery laboratories.