LCGC North America-04-01-2005

LCGC North America
LC Troubleshooting

April 01, 2005

When is it time to throw in the towel?

This month's installment of "Column Watch" is the conclusion of a two-part series in which Ron Majors examines the trends in column introductions at Pittcon 2005. Here, he discusses gas chromatography columns, sample preparation products, hardware, and accessories.

Co-occurrence of several mycotoxins (deoxynivalenol, zearalenone, T-2-toxin, HT-2 toxin) produced by field fungi, such as Fusarium graminearum and Fusarium culmorum, requires several analysis methods for their characterization. A reliable method for the determination of type A- and B-trichothecenes and zearalenone in cereal-based samples is presented. To achieve optimal mass spectrometric detection, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) were compared. Best results were obtained with ESI by implementing a two-period switching for the ionization polarity. The limit of quantification differs for each individual substance within the range 1–10 ppb. Mean recoveries using a standardized clean-up procedure were in the 54–93% range.

process is interesting and involved, and in this month's installment of "MS - The Practical Art," Michael Balogh continues the Profiles in Practice series by exploring this topic with featured scientists Michele Kelly and Mark Kershaw.

LCGC North America

April 01, 2005

Short Courses

The authors discuss a solid-phase extraction (SPE) clean-up procedure for drugs present in biofluids.

LCGC North America
Peaks of Interest

April 01, 2005

A thorough consideration of 30 nominated instruments by 21 nominating editors resulted in a clear runaway for the top product at this year's Pittcon. The gold award was presented to JEOL (Peabody, Massachusetts) for its DART ionization technology for MS.

LCGC North America

April 01, 2005

Calendar

LCGC North America

LC-MS monitoring of the drug clozapine is detailed along with a description of the overall system architecture, workflow, and maintenance routines that spport a large-scale drug monitoring program.