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LCGC North America-04-01-2005
LCGC North America
New Chromatography Columns and Accessories at the 2005 Pittcon Conference: Part II
April 01, 2005
Column Watch
23
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This month's installment of "Column Watch" is the conclusion of a two-part series in which Ron Majors examines the trends in column introductions at Pittcon 2005. Here, he discusses gas chromatography columns, sample preparation products, hardware, and accessories.
Analysis of Fusarium Toxins Using LC–MS-MS: Application to Various Food and Feed Matrices
April 01, 2005
Peer-Reviewed Articles
23
4
Co-occurrence of several mycotoxins (deoxynivalenol, zearalenone, T-2-toxin, HT-2 toxin) produced by field fungi, such as Fusarium graminearum and Fusarium culmorum, requires several analysis methods for their characterization. A reliable method for the determination of type A- and B-trichothecenes and zearalenone in cereal-based samples is presented. To achieve optimal mass spectrometric detection, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) were compared. Best results were obtained with ESI by implementing a two-period switching for the ionization polarity. The limit of quantification differs for each individual substance within the range 1–10 ppb. Mean recoveries using a standardized clean-up procedure were in the 54–93% range.
Profiles in Practice Series: Stewards of Drug Discovery — Developing and Maintaining the Future Drug Candidates
April 01, 2005
MS - The Practical Art
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process is interesting and involved, and in this month's installment of "MS - The Practical Art," Michael Balogh continues the Profiles in Practice series by exploring this topic with featured scientists Michele Kelly and Mark Kershaw.
Control of Matrix Effects in Bioanalytical MS–MS Using On-line Multidimensional Solid-Phase Extraction
April 01, 2005
Peer-Reviewed Articles
23
4
The authors discuss a solid-phase extraction (SPE) clean-up procedure for drugs present in biofluids.
Peaks of Interest
April 01, 2005
Peaks of Interest
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A thorough consideration of 30 nominated instruments by 21 nominating editors resulted in a clear runaway for the top product at this year's Pittcon. The gold award was presented to JEOL (Peabody, Massachusetts) for its DART ionization technology for MS.
A High-Volume, High-Throughput LC–MS Therapeutic Drug Monitoring System
April 01, 2005
Peer-Reviewed Articles
23
4
LC-MS monitoring of the drug clozapine is detailed along with a description of the overall system architecture, workflow, and maintenance routines that spport a large-scale drug monitoring program.