Analytical Strategies for Complex Biotherapeutics

The Intabio ZT system integrates imaged capillary isoelectric focusing (icIEF) with UV detection and mass spectrometry (MS) to rapidly separate, quantify, and identify biopharmaceutical charge variants in a single workflow. In this webinar, learn how your biopharma peers are applying icIEF-UV/MS with the Intabio ZT system to gain deeper insight into protein structure, function, and stability—accelerating analytical development and decision-making.

Register Free: https://www.biopharminternational.com/bp_w/biotherapeutics

Event Overview:

The Intabio ZT system integrates imaged capillary isoelectric focusing (icIEF) with UV detection and mass spectrometry (MS) to rapidly separate, quantify, and identify biopharmaceutical charge variants in a single workflow. This capability makes it a powerful tool for gaining high-resolution insights into protein structure, function, and stability—from early cell line development through formulation.
In this webinar, learn how your biopharma peers are applying icIEF-UV/MS with the Intabio ZT system to strengthen analytical strategies and accelerate decision-making. Topics include:

• Charge variant analysis via icIEF-UV/MS: See how this integrated technique provides detailed structure-function insight for complex molecules such as Fc fusion proteins.
• Stability assessment through forced degradation: Explore how intact and subunit icIEF-UV/MS workflows can reveal key stability profiles and support robust formulation development.

Join this session to discover practical, data-driven approaches for addressing the analytical challenges of modern protein therapeutics.

Key Learning Objectives:

• Learn how to facilitate in-depth characterization of highly glycosylated and sialylated fusion proteins.
• Discover how to develop a platform method for charge heterogeneity characterization of complex therapeutics.
• See how to achieve rapid assessments of stability in forced degradation studies.

Who Should Attend:

• Analytical scientists in Biopharma
• Process development scientists
• Researchers with roles in the development of next-generation biologics

Speakers

Anita Liu is an Associate Principal Scientist in the Biologics Mass Spectrometry (MS) group at Merck & Co., focusing on MS-based method development and technological innovation to advance biotherapeutic characterization. She earned a BS in Chemical Engineering from Princeton University and an MS in Chemical Engineering from Cornell University.
Anita began her career in mass spectrometry at ExSAR, where she applied hydrogen-deuterium exchange MS (HDX-MS) to higher-order structure analysis of antibody drugs. She then joined Regeneron Pharmaceuticals, leading the development of anion-exchange chromatography–MS (AEX-MS) for charge variant analysis in monoclonal antibodies and hydrophilic-interaction chromatography–MS (HILIC-MS) to assess quality attributes in adeno-associated virus capsids. At Merck, she continues to explore innovative MS approaches, including the coupling of imaged capillary isoelectric focusing with UV and MS detection (icIEF-UV/MS).

Anita has over 15 years of industry experience in MS-based protein characterization and separation science.

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Jingwen Ding, PhD, is a Senior Technical Product Manager at SCIEX, focusing on the development and refinement of imaged capillary isoelectric focusing with ultraviolet detection and mass spectrometry (icIEF-UV/MS) workflows to provide reliable charge heterogeneity information. She earned a PhD in Chemistry from the University of Connecticut and a BS from Nankai University.

Register Free: https://www.biopharminternational.com/bp_w/biotherapeutics