Chromatography of Biotherapeutics: Analyzing and Purifying Peptides and Oligonucleotides

Join the experts of YMC to explore innovative chromatographic solutions that are advancing the analysis and purification of peptides and oligonucleotides with greater resolution, sensitivity, and reliability. Learn how optimized methods and bioinert technologies are enabling more efficient characterization, purification, and quality control of next generation biotherapeutics.

Register Free: https://www.chromatographyonline.com/lcgc_w/purifying-peptides

Event Overview:

This webinar will highlight how advanced ultra-high-performance liquid chromatography (UHPLC) strategies, carefully selected stationary phases, and bioinert hardware can significantly improve the analysis and purification of peptides and oligonucleotides by enhancing resolution, recovery, and sensitivity. Using the GLP-1 receptor agonist tirzepatide as a representative example, attendees will gain practical insights into chromatographic method development, from analyte assessment and mobile phase selection to stationary phase screening and final method optimization. The webinar will also demonstrate the impact of bioinert hardware on chromatographic performance and show how tailored chromatographic approaches can support reliable characterization, improved reproducibility, and robust quality control of modern biotherapeutics.

Key Learning Objectives

• Learn why peptide and oligonucleotide analysis requires tailored chromatographic conditions.
• Understand how stationary phase chemistry and pore size are critical for separation.
• Explore how bioinert column hardware greatly improves peak shape, sensitivity, and recovery.

Speakers:

Dr. Daniel Eßer
Product Manager, Analytical Chromatography
YMC Europe GmbH

Daniel Eßer studied chemistry at the University of Applied Sciences Bonn‑Rhein-Sieg, in Rheinbach, Germany, with a focus on pharmaceutical and analytical chemistry. He received his Ph.D. in pharmaceutical and medicinal chemistry at the University of Düsseldorf, Germany. During his postdoc at the Institute of Pharmaceutical and Medicinal Chemistry of the University of Düsseldorf, he established a nano LC–MS system. In 2013, he joined YMC Europe in Dinslaken, Germany, as product specialist in analytical chromatography. Since 2017, he has been responsible for YMC’s analytical (U)HPLC column portfolio as product manager of analytical chromatography.

J Preston, PhD
Director, Separation Sciences
YMC America

J Preston, Ph.D. has been with YMC America for over 5 years as the Director of Separation Sciences. He has nearly 30 years of experience focused on chromatography in the pharmaceutical industry. Dr Preston spent 15 years with Amgen, Pfizer-Pharmacia-GD Searle and Abbott Labs. Prior to joining YMC America, Dr. Preston spent 9 years at the Phenomenex Corporation as the Manager and Principal Scientist in their applications lab and as the Global Product manager for their Chiral, Prep and Bulk product lines. Dr. Preston has a Doctorate in Analytical Chemistry from the University of Illinois at Urbana-Champaign and has published numerous peer reviewed articles. He also has given many presentations at national and international meetings.

Register Free: https://www.chromatographyonline.com/lcgc_w/purifying-peptides