YMC, Inc | Authors


Native online SCX-MS of monoclonal antibodies

In this application note high resolution SCX was coupled directly to an ultrasensitive online native MS using YMC’s BioPro IEX SF to analyse mAb charge variants.

Challenging analysis of Amyloid β proteins

Amyloid β proteins are highly hydrophobic and can form aggregates. The analysis of 4 Aβ using YMC-Triart Bio C4 with larger pore and lower hydrophobicity is presented.

Investigation of Pore Size, Particle Size, and Column Geometry Effects on SEC Analysis of Monoclonal Antibodies

This work focused on scaling-down a monoclonal antibody SEC method, starting with a typical analytical-size SEC column (YMC-Pack Diol 5um, 300Å, 300x8.0mm) and ending with a small particle, shorter length, narrower-bore column (YMC-pack Diol 2um, 300Å, 150x4.6mm). The purpose of this experiment was to detail the differing performance characteristics exhibited by each column as physical properties were altered, one variable at a time.