
News|Articles|August 17, 2026
CPME-HPLC Method Detects Four Tetracyclines in Urine
A multinational research team developed a green, miniaturized CPME-HPLC-DAD method to simultaneously extract and detect four tetracyclines in human urine, offering a simpler, cheaper alternative to LC-MS/MS with improved sensitivity. LCGC International spoke to Fedra Vasileiou, Victoria Samanidou, and Abuzar Kabir, three of the authors of the paper that resulted from this work.
Advertisement
Advertisement
Tetracyclines are widely used antibiotics that fight a broad range of bacteria, commonly treating urinary tract infections, acne, respiratory infections, and skin infections. Since the first one was discovered decades ago, they have evolved into three "generations," with tetracycline, oxytetracycline, doxycycline, and chlortetracycline now most common.
Related to this article

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) finds low glyphosate residues of the weedkiller glyphosate in coffee beans.

This week, Chromatography Online explored how the technique is advancing wastewater drug monitoring, siRNA method development, and food safety testing, with previews of RAFA 2026 and a return to HPLC fundamentals with Michael Dong.

Recent EU legislation on PFAS shifts from monitoring individual compounds toward managing them as a chemical class.

In this seventh part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explains why 2.1-mm i.d. columns are less preferred for pharmaceutical quality control.

Ultrahigh-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) shows how soaking and cooking break down soybean fats.

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) links altered metabolism to lingering symptoms in Ebola survivors.

Nicolai Zederkopff explores chromatography’s role to help implement the maximum tolerable level (MTL) framework for food adulteration to translate analytical results into compliance decisions.
Advertisement
Advertisement

