Magnetic molecularly imprinted polymer extraction with liquid chromatography-high resolution mass spectrometry (LC–HRMS) finds patulin in store-bought juice.
News|Articles|October 9, 2025
Examining Column Selectivity Differences Across Various L1 Designation Columns for Paracetamol EP Impurities Monograph (Oct 2025)
Author(s)Waters Corporation
he United States Pharmacopeia (USP) has designations for all columns stationary phases used in the monograph methods. These designations outline the stationary phase type, i.e. fully porous or solid-core, and any ligand attachments, i.e. C18 or Phenyl to be used.1 However, beyond that no column specifics are given. With a multitude of columns that fit into the different designations, understanding that not all columns are the same is vital when selecting a stationary phase for a monograph method. This application note examines three columns that all fit into the L1 designation when analyzing paracetamol impurities. Selectivity differences between the columns are considered in relation to the impurities.
Related to this article
Richard Bade and Malcolm McLeod explain to LCGC International how chromatography detects drug trends in wastewater.
In this fifth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses how to overcome challenges with reversed-phase chromatography in drug analysis.
Liquid chromatography–tandem mass spectrometry (LC–MS/MS) and microbiome data reveal kidney markers of diabetic disease.
Ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) shows Maresin1 drops in heatstroke and may protect the heart.
This week on Chromatography Online, leading experts shared practical insights with LCGC International on sustainable affinity methods, siRNA impurity profiling, nontarget screening, peptide tech transfer, and AI in separation science.
Liquid chromatography–mass spectrometry (LC–MS) was used to determine if there is a link between artificial sweeteners and breast cancer.
Chiral gas chromatography–mass spectrometry (GC–MS) shows how heat and storage alter linalool in blueberry juice.
Trending on LCGC International
1
Prioritizing Unknowns in Nontarget Screening of Food Samples
2
Conversations with Michael Dong: Overcoming Challenges with Reversed-Phase Chromatography in Drug Analysis
3
Chromatography Tracks Drugs in Australian Wastewater
4
Conversations with Michael Dong: Buffers for Mobile Phase A in Pharmaceutical Analysis
5