Fast LC for High-Throughput LC–MS

Steven Ray Wilson's AFFL LC–MS system runs thousands of injections per column, but he calls validation and standardization the field's real barrier.

A novel SFC–QTOF-MS method accurately detected 10 drugs in oral fluid, matching LC–MS/MS in 83 DUID cases while reducing run time by 42% and organic solvent use by 81%.

Steven Ray Wilson defines organ-on-a-chip as organoids on microfluidic devices, tracing their small, complex samples to the case for automated online LC–MS.

Gérard Hopfgartner explains why pairing SFC with dopant-assisted APPI can match, or even beat, electrospray sensitivity, even at microflow LC rates.

Gérard Hopfgartner explains how atmospheric pressure photoionization can generate radical cations in LC–MS, unlocking EI-style spectra and NIST's spectral library.