LCGC TV: Gérard Hopfgartner on Advances in Ion Mobility Mass Spectrometry
Performing liquid chromatography–mass spectrometry (LC–MS) analysis on tissue samples requires sample homogenization, which destroys the sample and loses its spatial resolution. Gérard Hopfgartner from the University of Geneva, University of Lausanne, Switzerland, presents an alternative method coupling liquid extraction surface analysis with modifier-assisted differential ion mobility spectrometry, describes other application areas, and gives his opinion on whether this is the beginning of the end for chromatography.
In this fifth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses how to overcome challenges with reversed-phase chromatography in drug analysis.
This week on Chromatography Online, leading experts shared practical insights with LCGC International on sustainable affinity methods, siRNA impurity profiling, nontarget screening, peptide tech transfer, and AI in separation science.
Anneli Kruve reports that toxicity predictions from MS2-derived molecular fingerprints outperform spectral-similarity methods in nontarget screening of food.
In this fourth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explains why buffers are most often used in Mobile Phase A in high-pressure liquid chromatography of pharmaceuticals.
