News | Articles | August 16, 2024
Modern HPLC Strategies That Improve Retention and Peak Shape for Basic Analytes In high-performance liquid chromatography (HPLC), it is common for bases and unreacted ionized silanols on silica-based columns to cause irreproducible retention, broad peaks, and peak tailing when working with basic analytes. David S. Bell, Lead Consultant at ASKkPrime LLC offers innovative HPLC strategies that can help mitigate such issues.
Newsletter Join the global community of analytical scientists who trust LCGC for insights on the latest techniques, trends, and expert solutions in chromatography.
Subscribe
September 29th, 2026 Ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) shows flonicamid residues in rice pose negligible dietary risk.
September 29th, 2026 Meet the expert panel exploring the challenges involved in GLP-1 analysis in this LCGC International Peer Exchange®.
September 29th, 2026 High-performance liquid chromatography-tandem mass spectroscopy (HPLC–MS/MS) chromatography reveals pyrrolizidine alkaloids (PA)/pyrrolizidine alkaloid N-oxides (PANO) toxin risks in 63 tea samples.
September 29th, 2026 Advances in DNA/RNA chromatography columns led to stable, pure mRNA production, supporting the development of COVID-19 vaccines rapidly.
September 29th, 2026 Steven Ray Wilson's AFFL LC–MS system runs thousands of injections per column, but he calls validation and standardization the field's real barrier.
September 29th, 2026 Kinjal Bhatt and Ina Varfaj describe imposter syndrome fading through repeated exposure and conference talk rather than a single breakthrough moment.
September 28th, 2026 Mass spectrometry can teach core chemistry concepts beyond technique training or product characterization, though adoption barriers remain.
September 28th, 2026 Automated sequential tube sampling and chemometrics supplement GC–MS, adding time profiling and fast product-line comparison for real-world insight.