A mass spectrometer from Thermo Fisher Scientific, Inc. has been chosen by the Institut de Recherches Cliniques de Montreal (ICRM) for use in their proteomics research approach that could impact the current understanding of the human proteome.
A mass spectrometer from Thermo Fisher Scientific, Inc. has been chosen by the Institut de Recherches Cliniques de Montreal (ICRM) for use in their proteomics research approach that could impact the current understanding of the human proteome.
Dr. Benoit Coulombe, his research team at ICRM, and collaborators in various universities and research centers are conducting the research project, called the Human Proteotheque Initiative (HuPI). The overall goal of the project is to define the maps of protein interactions that regulate cell growth, differentiation, and disease progression. Central to the project is its experimental platform, including the LTQ Orbitrap linear ion trap mass spectrometer, which generates maps of protein interaction networks.
This information potentially can lead to future groundbreaking discoveries of new molecular tools for the prevention and treatment of disease.
"What is most important is to develop a highly reliable and efficient discovery pipeline that generates interaction maps that are both as complete and as accurate as possible. The specificity of our procedure to identify functionally relevant interaction partners is spectacular," said Dr. Coulombe.
HPLC 2025 Preview: The Present and Future of Automation in Analytical Laboratories
May 22nd 2025Analytical laboratories are undergoing a fundamental transformation. In the face of increasing sample volumes, growing regulatory requirements, and the rising demand for faster, more precise, and cost-efficient analysis, optimizing laboratory processes is becoming a central focus. Automation technologies offer promising solutions in this regard. Recently, they have evolved from isolated solutions to comprehensive systems that permeate nearly all areas of laboratory practice. This development not only opens up new opportunities in terms of efficiency, data quality, and scalability but also brings technical, organizational, and personnel challenges. To successfully address these, strategic approaches are needed that consider both the technological and human dimensions of the transformation.
Quantifying Isavuconazole in Dried Blood Spots Using HPLC
May 21st 2025Isavuconazole, an antimycotic agent used to treat fungal infections, can typically be found during dried blood spot sampling. However, there are obstacles that keep it from being an ideal approach for properly determining the drug’s presence.
Separating and Quantifying Spinach Flavonoids with UHPLC–MS/MS
May 21st 2025Researchers at Baylor College of Medicine’s Children's Nutrition Research Center (Houston, Texas) developed and validated a high-throughput extraction and ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method to separate and quantify 39 spinach flavonoid species in 11.5 min.