John Chasse | Authors

Top-down mass spectrometry (TD-MS) of peptides and proteins results in product ions that can be correlated to the polypeptide sequence. Joseph Loo and colleagues at the University of California-Los Angeles (UCLA) have developed ClipMS, an algorithm assigning both terminal and internal fragments generated by TD-MS fragmentation, which can be used to locate various modifications on the protein sequence.

Glen Jackson, Professor of Forensic and Investigative Science at West Virginia University, presented an "Expert Algorithm for Substance Identification (EASI): A New Paradigm for Mass Spectral Identifications" at SciX 2021, where it earned the FACSS Innovations Award. These awards are given for the most innovative and outstanding new research advancements debuted orally at the SciX Conference. Jackson spoke to Current Trends in Mass Spectrometry about his presentation.

Rebecca Gowland and her colleagues in the Department of Archaeology at Durham University in the United Kingdom have tested, for the first time, the applicability of a new method of sex estimation utilizing enamel peptides from a sample of permanent and deciduous teeth at different stages of mineralization, from nonadults of unknown sex, including perinates, and using a minimally destructive acid etching procedure and subsequent nano liquid chromatography– tandem mass spectrometry. She spoke to us about her efforts.

A preview of this year’s ASMS conference, in its new online format.

This Wednesday morning session begins at 9:00 am with Leonard Sidisky, Jamie Desorcle, Greg Baney, and Kathy Kiefer of MilliporeSigma presenting “Latest Developments in Ionic Liquid Stationary Phase Technology.”

This afternoon session begins at 1:30 p.m. with a keynote lecture titled “In-vivo SPME with Matrix Compatible Coatings Coupled to LC–MS and Directly to MS,” presented by Janusz Pawliszyn of the University of Waterloo (Waterloo, Canada).