Linking LC-HRMS Features to Aquatic Toxicity: A Nontargeted Approach Without Compound Identification
July 7th 2025A recent study conducted by the University of Amsterdam (Amsterdam, Netherlands) and the University of Queensland (Queensland, Australia) developed a novel prioritization strategy that directly links fragmentation and chromatographic data to aquatic toxicity categories, bypassing the need for identification of individual compounds. LCGC International spoke to Viktoriia Turkina of the University of Amsterdam, lead author of the paper that resulted from this study, about their work.
Detection and Risk Assessment of Mycotoxins in Commercial Tortillas Using HPLC-Based Methods
July 4th 2025A joint study between Selçuk University (Konya, Turkey) and Hitit University (Corum, Turkey) determined the natural occurrence and concentrations of the mycotoxins ochratoxin A (OTA) and deoxynivalenol (DON) in commercially available tortillas in Turkey. Contamination levels were quantified using validated analytical methods based on high-performance liquid chromatography (HPLC) coupled with fluorescence or ultraviolet detectors (HPLC-FLD or HPLC–UV).
GC Analysis Reveals PCB Accumulation in Antarctic Penguins and Krill
July 3rd 2025Researchers from the University of Murcia (Murcia, Spain), the Carlos III Health Institute (Madrid, Spain), and the University of Siena (Siena, Italy) evaluated the concentration of polychlorinated biphenyls (PCBs) in chinstrap penguins and krill from Deception Island (South Shetland Islands, Antarctica) to provide additional data of the PCB presence in Antarctica. To this end, 34 samples of different tissues corresponding to four adult specimens and six chicks were analyzed with gas chromatography.
Endogenous Gibberellin Acid Levels Tracked Across Developmental Stages in Cauliflower
July 1st 2025Researchers at the ICAR-Indian Agricultural Research Institute (New Delhi, India) investigated the endogenous levels of gibberellins (GAs) at six different developmental stages and four time points in four varieties of cauliflower using high-performance liquid chromatography (HPLC).
New Research Examines Role of Serum Metabolites in Colon Cancer Risk Assessment
June 26th 2025A recently published study set out to determine whether serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk. Serum samples were analyzed using liquid chromatography-mass spectrometry (LC-MS).
Characterizing Terpene Emissions from Indoor Cannabis Facilities Using GC-FID
June 24th 2025A study conducted by researchers at the University of British Columbia (Vancouver, Canada) used gas chromatography coupled with flame ionization detection (GC-FID) to develop an automated sampling protocol applied to indoor rooms of a cannabis cultivation and a cannabis processing facility to investigate the temporal concentration profile and emissions of 22 terpenes.
Pharmacokinetics of Oral Gabapentin in Goats: Insights from RP-HPLC Analysis
June 19th 2025A study conducted by the College of Veterinary Medicine of Midwestern University (Glendale, Arizona), the University of California Davis School of Veterinary Medicine (Davis, California) and the College of Veterinary Medicine of the University of Tennessee (Knoxville, Tennessee) set out to describe the pharmacokinetics of oral gabapentin (GABA) in goats given as a single dose (SD) and multidose (MD) regimen, as well as to document any adverse effects after administration. Plasma samples were collected and analyzed via reversed-phase high performance liquid chromatography (RP-HPLC).
Determining the Optimal Harvest Period for Koroneiki Olives with GC-IMS
June 11th 2025Researchers at the College of Life Science at Northwest Normal University (Lanzhou, China) used gas chromatography-ion mobility spectrometry (GC-IMS) to analyze the volatile organic compounds (VOCs) of olive oil extracted from eight maturity indices of Koroneiki olive fruits to determine the optimal harvest period.
Determining the Neuroprotective Potential of Celery in Alzheimer’s Disease Therapy with LC–MS
June 5th 2025Research conducted at Uskudar University (Istanbul, Turkey) explored the neuroprotective potential of ethanolic extracts of celery leaves, specifically in the treatment of Alzheimer’s disease. Liquid chromatography (LC) and mass spectrometry (MS)-based metabolomics analysis of the extract revealed the existence of a diverse array of secondary metabolites, including phenolic acids, hydroxycinnamic acid, flavonoids, flavonoid O-glycosides, flavonol, glycosides, and isoflavones.
Characterizing Nutritional and Chemical Content of Red and Purple Potato Peels
June 4th 2025A recent study aiming to investigate, for the first time, the biochemical and nutritional composition of the peels from five purple and two red potato cultivars and evaluate them as sources of healthy ingredients for the formulations of nutraceuticals quantified total phenolic content, carbohydrates, proteins, and lipids using UV–visible (UV-vis) spectrophotometry. The phytochemical composition was further characterized via high-performance liquid chromatography coupled with a diode-array detector (HPLC-DAD).
Exploring the Effect of Sound on Beer Fermentation Using GC-MS
May 29th 2025Researchers at the University of Otago (Dunedin, New Zealand) and the University of Auckland (Auckland, New Zealand) out to show that applying audible sound via a linear actuator, which impacted primarily on particle motion rather than the pressure component of audible sound, would significantly decrease beer fermentation time compared to control fermentations by keeping more viable yeast in suspension. Gas chromatography-mass spectrometry (GC-MS) was used to measure the abundance of volatile organic compounds (VOCs) in the beer samples.
Uncovering Metabolic Pathways in the Hyperglycemic Bone with LC-MS
May 28th 2025Researchers at the University of Porto (Porto, Portugal) aiming to uncover novel therapeutic targets for bone loss of functionality and enhancing the understanding of its underlying bioenergetic mechanisms used liquid chromatography-mass spectrometry (LC-MS) to characterize proteomes.
LC-HRMS Detection of Pharmaceuticals and Other Compounds in Cruise Ship Wastewater
May 27th 2025Treated wastewater from three expedition North Atlantic Ocean cruise ships was collected and analyzed with a focus on pharmaceuticals, personal care products, and industrial chemicals. Samples were screened using data-dependent acquisition using liquid chromatography-high-resolution mass spectrometry (LC-HRMS).
Sil-DBO-PS: A Zwitterionic Phase for Enhanced HILIC of Polar Compounds
May 26th 2025A joint study conducted by the Henan University of Technology (Zhengzhou, China) and the Food Laboratory of Zhongyuan (Henan Province, China) developed and evaluated what the researchers deemed a novel zwitterionic stationary phase, Sil-DBO-PS, for hydrophilic interaction liquid chromatography (HILIC).LCGC International spoke to Ashraf Ali of the Henan University of Technology about this research and their findings.
Interpreting Metabolites and Biosynthetic Pathways of Musk with GC–MS
May 22nd 2025Gas chromatography–mass spectrometry (GC–MS) was used to detect the chemical components of natural musk, harvested from forest musk deer at multiple stages of maturity. This research combines metabolomic profiling with biosynthetic pathway analysis to identify potential precursors and enzymes involved in musk biosynthesis.
Separating and Quantifying Spinach Flavonoids with UHPLC–MS/MS
May 21st 2025Researchers at Baylor College of Medicine’s Children's Nutrition Research Center (Houston, Texas) developed and validated a high-throughput extraction and ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method to separate and quantify 39 spinach flavonoid species in 11.5 min.
Hydrophilic Interaction Chromatography (HILIC) and Direct Online Disruption of Lipid Nanoparticles
May 19th 2025Two proof-of-concept hydrophilic interaction chromatography HILIC) methods were developed in a joint study conducted by the University of Geneva (Switzerland), Sanofi, and the Waters Corporation—one for disrupting LNPs and retaining the mRNA, and another for detecting only unencapsulated mRNA to assess encapsulation efficiency. LCGC International spoke to Jonathan Maurer, first author of the paper that resulted from this study, about the methods and the efforts that led up to their development.
Quantifying Inorganic Carbon in Soil Using Sulfamic Acid and Gas Chromatography
May 15th 2025Researchers at Andes Ag, Inc. (Alameda, California) established a high-throughput framework for the robust and precise quantification of soil inorganic carbon (SIC) from agricultural soils using gas chromatography (GC).
Measuring Vitamin K1 Concentrations in Dogs with Chronic Enteropathy Using LC–MS/MS
May 14th 2025A joint study between the University of Tennessee (Knoxville, Tennessee) and the University of Pennsylvania School of Veterinary Medicine (Philadelphia, Pennsylvania) compared directly measured vitamin K1 (vitK1) concentrations in healthy dogs and dogs with chronic enteropathy (CE) using liquid chromatography tandem mass spectrometry (LC–MS/MS); they also investigated whether supplementation of vitK1 in dogs with CE would significantly increase vitK1 concentrations.
Determining Ways to Protect Honeybee Colonies with GC–MS
May 13th 2025A study conducted by the Agriculture Research Centre of Giza, Egypt, and Jilin Agricultural University in China, evaluated the efficacy of stinging nettle extract, nettle smoke, and formic acid in the controlling of Varroa mites, a major threat to honeybee colonies, with a focus on mite infestation reduction, honeybee mortality, and biochemical responses. Gas chromatography–mass spectrometry (GC–MS) was used to identify key bioactive compounds in the stinging nettle extract.