Peptide Purification: From HPLC Origins to Process Intensification

Peptide purification has moved from pioneering HPLC separations to an era of unprecedented scale. See how smarter method development, scale-up, and process intensification are helping meet the demands of modern peptide manufacturing.

Register Free: https://www.chromatographyonline.com/lcgc_w/intensification

Event Overview:

This presentation explores the evolution of peptide purification, from the early days of reversed-phase HPLC to today's large-scale manufacturing challenges. It covers practical strategies for preparative method development, stationary phase selection, and efficient scale-up, illustrated by a case study on tirzepatide purification. The session also introduces continuous chromatography using MCSGP technology and highlights its potential for process intensification in modern peptide manufacturing.

Key Learning Objectives

• Trace the journey from HPLC origins to modern peptide purification.
• Turn complexity into purity with smarter method development and scale-up.
• Rethink purification with MCSGP and continuous chromatography.

Speakers

Marc Jacob, PhD
Head of Strategic Development
YMC America

Marc Jacob, PhD, is the head of strategic development for chromatography products at YMC America, bringing strong expertise in process chromatography and business development. Throughout his career, Jacob has held key roles in leading CDMOs, including Bachem and SK pharmteco. He holds a doctorate in organic chemistry from the University of Montpellier and completed a postdoctoral fellowship at Texas A&M University under Nobel Laureate Sir Derek Barton.

Elena Rath
Product Specialist Preparative Chromatography
YMC Europe GmbH

As a product specialist, Elena Rath focuses on chromatographic method development, scale-up, and preparative purification. She supports purification projects involving a variety of target compounds, from the initial selection of suitable chromatographic conditions to their transfer to preparative scale, providing technical guidance throughout the process.

Register Free: https://www.chromatographyonline.com/lcgc_w/intensification