Precision Metabolomic Profiling in Asthma Research via LC–MS/MS
Korean researchers utilized liquid chromatography-tandem mass spectrometry (LC–MS/MS) to quantify serum metabolites in asthma patients. By leveraging the high-resolution separation of LC combined with the sensitive detection of MS/MS, researchers can identify specific metabolic signatures, providing critical insights into the biochemical pathways and potential biomarkers associated with asthma progression.
As the biochemical basis of asthma is not yet fully understood, researchers from The Catholic University of Korea, the Korea University College of Medicine, and Seoul National University (all in Seoul, Korea) came together to identify distinct serum metabolomic clusters in asthma and to evaluate their associations with physiologic and structural indicators of small airway involvement. Serum metabolites were quantified using proton nuclear magnetic resonance spectroscopy and liquid chromatography tandem mass spectrometry (LC–MS/MS). A paper based on this research was recently published in The Journal of Asthma and Allergy.1