This week, Chromatography Online explored how the technique is advancing wastewater drug monitoring, siRNA method development, and food safety testing, with previews of RAFA 2026 and a return to HPLC fundamentals with Michael Dong.
News|Articles|January 30, 2025
Rapid and Quantitative Screening of Nitrosamines in Drug Products Using Headspace-SIFT-MS
Author(s)Syft Technologies Inc
This study demonstrates that headspace-SIFT-MS meets United States Pharmacopeia (USP) criteria for six nitrosamines, achieving low limits of quantitation (0.06 ppm for NDMA and 0.03 ppm for NDEA) even in complex drug matrices. With high recovery rates and significant reductions in solvent usage, consumables, and operational complexity compared to traditional chromatographic methods, the Syft Tracer Pharm11 solution is an efficient screening tool for nitrosamines and volatile impurities.
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