Syft Technologies Inc

Explore advancements in utilizing alternative solvents for SIFT-MS. This tech note introduces three new solvents—acetonitrile, N,N'-dimethylpropyleneurea (DMPU), and propylene glycol (PG)—and highlights the enhanced sensitivity and applications of existing solvents like triacetin. The findings demonstrate significant benefits in analyzing diverse VOCs while addressing challenges in method development.

SIFT-MS instruments show exceptional reproducibility. By comparing standardized analytical methods on multiple instruments, it demonstrates high consistency in trace gas quantitation with 95% confidence intervals below 21% for the Syft Tracer and 38% for legacy devices. The findings emphasize Syft's commitment to advancing reliable, real-time analysis solutions for diverse applications.

Learn about the world's only 21 CFR Part 11 compliant real-time mass spec, Syft Tracer Pharm11. It is a high-throughput solution for compliant pharma and CDMO workflows.

This study demonstrates that headspace-SIFT-MS meets United States Pharmacopeia (USP) criteria for six nitrosamines, achieving low limits of quantitation (0.06 ppm for NDMA and 0.03 ppm for NDEA) even in complex drug matrices. With high recovery rates and significant reductions in solvent usage, consumables, and operational complexity compared to traditional chromatographic methods, the Syft Tracer Pharm11 solution is an efficient screening tool for nitrosamines and volatile impurities.

This application note highlights the capabilities of SIFT-MS for real-time measurement of EPA-regulated Hazardous Organic NESHAP (HON) compounds. By achieving sub-pptV method detection limits, it demonstrates the technology's suitability for regulatory fenceline monitoring and rapid source identification.

This study demonstrates high-throughput analysis of BTEX compounds from several matrices (air, water and soil). Detection limits in the single-digit part-per-billion concentration range (by volume) are readily achievable within seconds using SIFT-MS because sample analysis is achieved without chromatography, pre-concentration, or drying. We also present a calibration approach that enables speciation of ethylbenzene from the xylenes in real-time.

This application note summarizes key SIFT-MS results presented in a peer reviewed article entitled “Unreported VOC Emissions from Road Transport Including from Electric Vehicles.” Learn how the Wolfson Atmospheric Chemistry Laboratory at the University of York used SIFT-MS for VOC analysis in its platform to experimentally verify that motor vehicle screen wash is a significant unreported source of VOC emissions (especially for ethanol and methanol).

Method detection limits (MDLs) have been determined for the newly regulated HON (Hazardous Organic NESHAP (National Emission Standards for Hazardous Air Pollutants)) compounds, which validate selected ion flow tube mass spectrometry (SIFT-MS) as an effective solution for measuring these toxic volatile organic compounds (VOCs) and other environmental pollutants in ambient air, whether at the fenceline or in a mobile setting. SIFT-MS offers unparalleled speed, sensitivity and ease of use for environmental monitoring applications.

In this article, the results of a DIMS air monitoring campaign in Auckland, New Zealand, are described. Real-time SIFT–MS measurements were obtained at three sites over a period of several weeks. At each site, SIFT–MS provided effective on-site analysis to sub-ppbV levels with better than 1-min time resolution.

This application note describes the determination of method detection limits (MDLs) for the newly regulated HON (Hazardous Organic NESHAP) compounds, which validate SIFT-MS as an effective solution for measuring these toxic VOCs and other environmental pollutants in ambient air, whether at the fence line or in a mobile setting.

This study demonstrates high-throughput analysis of BTEX compounds from several matrices (air, water and soil). Detection limits in the single-digit part-per-billion concentration range (by volume) are readily achievable within seconds using SIFT-MS, because sample analysis is achieved without chromatography, pre-concentration, or drying. We also present a calibration approach that enables speciation of ethylbenzene from the xylenes in real-time.

This application note summarizes key SIFT-MS results presented in a peer reviewed article entitled “Unreported VOC Emissions from Road Transport Including from Electric Vehicles.” Learn how the Wolfson Atmospheric Chemistry Laboratory at the University of York used SIFT-MS for VOC analysis in its platform to experimentally verify that motor vehicle screen wash is a significant unreported source of VOC emissions (especially for ethanol and methanol).

This brochure SyftEnviro environmental monitoring software which is a comprehensive solution for visualizing data from mobile monitoring campaigns. It provides a user-friendly interface for collecting, mapping, and analyzing data taken by environmental monitoring technicians while investigating environmental emissions. SyftEnviro provides the tools to identify pollution sources and take immediate action.

This publication reviews VOC pollutant monitoring applications of SIFT-MS in South Korea. SIFT-MS has been applied to emission source characterization, fenceline monitoring, ambient monitoring, pollution mapping, and incident response (including the use of drone-based sampling) for hazardous air pollutants (HAPs), odor nuisance species, and compounds that have high ozone formation potential (OFP) and/or contribute to secondary aerosol (SOA) formation.

This application note describes a method for the rapid and simultaneous quantitation of benzene, 1,4-dioxane, and formaldehyde in personal care products (PCPs). Nine retail hair and skincare products from the United Kingdom were analyzed, with limits of quantitation (LOQs) for benzene in the low-ng g−1 range and 1,4-dioxane and formaldehyde in the sub- and low- μg g−1 range, respectively. Preliminary results indicate that SIFT-MS holds an 8- to 30-fold throughput advantage when compared to conventional gas chromatography (GC-MS).

At Pittcon 2024, Massood Kadir, Business Development Manager at Syft Technologies, gave a live demonstration of real-time trace gas analysis by SIFT-MS, a direct mass spectrometry technique.

In this article, the results of a DIMS air monitoring campaign in Auckland, New Zealand, are described. Real-time SIFT–MS measurements were obtained at three sites over a period of several weeks. At each site, SIFT–MS provided effective on-site analysis to sub-ppbV levels with better than 1-min time resolution.

This study demonstrates high-throughput analysis of BTEX compounds from several matrices (air, water and soil). Detection limits in the single-digit part-per-billion concentration range (by volume) are readily achievable within seconds using SIFT-MS, because sample analysis is achieved without chromatography, pre-concentration, or drying. We also present a calibration approach that enables speciation of ethylbenzene from the xylenes in real time.

This publication reviews VOC pollutant monitoring applications of SIFT-MS in South Korea. SIFT-MS has been applied to emission source characterization, fenceline monitoring, ambient monitoring, pollution mapping, and incident response (including the use of drone-based sampling) for hazardous air pollutants (HAPs), odor nuisance species, and compounds that have high ozone formation potential (OFP) and/or contribute to secondary aerosol (SOA) formation.

Headspace-SIFT-MS provides rapid and sensitive analysis of benzene and other contaminants in commercial products. It enables the daily screening of hundreds of samples.

Read about how the University of York used mobile SIFT- MS to experimentally verify that motor vehicle screen wash is a significant unreported source of VOC emissions

SIFT-MS has unique advantages in air quality measurement applications. It enables environmental incidents to be detected and remedied before they escalate.

This application note demonstrates that automated headspace-SIFT-MS analysis has the potential to screen larger sample numbers for the volatile MOH fraction, providing a rapid indication of packaging material contamination. As benzene has also recently been found to be problematic in commercial products, Headspace-SIFT-MS can screen over 220 samples per day for volatile MOSH and MOAH compounds – nearly seven-fold more samples than the routine liquid and gas chromatography method.

Quantitative analysis of volatile nitrosamine impurities in drug products is simplified using SIFT-MS and has a 3X throughput advantage over chromatographic methods.

In this study, Syft Tracer analyzed the same samples in 9 hours that took 5 chromatographic systems 24 hours to complete and still had capacity to spare.

Quantitative ethylene oxide analysis in Polysorbate 80 excipient is greatly simplified using SIFT-MS, with a time to first test result that is eight-fold faster than the current compendial method and a daily sample throughput that is 9- to 14-fold higher. In this application note, a simplified EtO method is presented that uses a much smaller quantity of PS80 for analysis than headspace GC-FID.

This application note describes head-to-head comparison of GC-FID and SIFT-MS analyses of Class 2A and 2B residual solvents. The techniques perform similarly for linearity and repeatability, but SIFT-MS provides superior performance for accuracy and recovery. Furthermore, SIFT-MS provides greater than 11-fold increase in sample throughput and significantly reduces the time taken to report quantitative results (over six times faster for a full calibration set).

This application note describes how SIFT-MS greatly simplifies formaldehyde detection and quantitation through direct, instantaneous, and sensitive (sub-ppbV) sample ionization. Sample throughputs of up to 250+ samples/day are possible using the method detailed in this study.

Quantitative analysis of volatile nitrosamine impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods. This application note describes the headspace-SIFT-MS analysis of ranitidine products which achieves a limit of quantitation of 2 ng g-1 for NDMA in 500 mg of drug product.