Smart-Subtract™ – Software for comparing complex GC–MS chromatograms

This week, LCGC International published a variety of articles on hot topics in separation science. Several analytical techniques were covered in these articles, including gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–MS (LC–MS).

Shifts in U.S. federal science funding—driven by the newly established Department of Government Efficiency (DOGE)—are causing delays, uncertainty, and program changes across academic and regulatory research institutions.

To better conduct the analysis of nucleoside analogues, hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC-MS/MS) was used to quantify antitumor prodrugs and their metabolites.

A new cancer detection test to analyze volatile organic compounds through urine analysis, was granted the Breakthrough Device Designation status by the U.S. FDA. The system, which is built on gas chromatography–mass spectrometry (GC–MS) and proprietary AI, generates real-time cancer risk scores.

Using two-dimensional liquid chromatography–mass spectrometry, a new workflow was developed to characterize phosphorodiamidate morpholino oligomers, which can help treat infectious diseases.