A full-stack capillary HPLC system, such as the one recently launched by Axcend, integrates several innovative features that set it apart from traditional HPLC systems. This compact system includes a 40-vial/96-well plate autosampler, an in-line process analytical technology (PAT) monitoring system, and a full-spectrum diode array detector (DAD). These components work together to enable real-time data analysis at the point of sampling, significantly enhancing productivity and precision. One of the most remarkable aspects of this system is its small footprint, which optimizes valuable lab and production space while reducing costs and environmental impact (the base measures 13" X 9"). The low-flow design minimizes solvent consumption and hazardous waste, aligning with sustainable laboratory practices. Additionally, the system's ability to perform HPLC anywhere—whether inside a hood or next to a reaction vessel—provides unparalleled flexibility for scientists.
Liquid chromatography–ion mobility spectrometry–high-resolution mass spectrometry (LC–IMS–HRMS) shows elephant seal pups carry more PFAS than their mothers do.
This week's Chromatography Online highlights include olive waste antioxidant recovery, food and tea analysis, EV isolation, mRNA vaccine purification, perfusion chromatography for oligonucleotides, mass spectrometry in teaching and career advice from “Women in Chromatography.”
Kinjal Bhatt and Ina Varfaj call AI a chromatography equalizer only if training and access keep pace, framing the risk as implementation, not technology.
Gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS) reveal lasting brain cholesterol loss after myelin damage.
Kinjal Bhatt would expose early-career scientists to the field sooner, while Ina Varfaj says a broken chromatography column taught her failure is normal.