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Alexander J. Krynitsky

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Important Considerations Regarding Matrix Effects When Developing Reliable Analytical Residue Methods Using Mass Spectrometry

Jon W. Wong;Hudan Safarpour;Alexander J. Krynitsky
July 1st 2017

Practical examples of how to correct for matrix effects in food testing to obtain reliable quantitative data using LC–MS and GC–MS

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Figure 1: Seven prioritization strategies in non-target screening (NTS) by chromatography–HRMS, grouped by domain: chemical information (P1–P3), toxicological information (P5–P6), external information (P4), and preprocessing (P2, P7). Each strategy narrows the candidate space based on specific criteria. Combined, they reduce complexity and focus identification on environmentally relevant features.
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