July 1st 2008Liquid chromatography with tandem mass spectrometry (LC–MS-MS) led to a revolution in environmental testing. The coupling of liquid chromatography with tandem mass spectrometry created a powerful analytical tool for the analysis of emerging environmental contaminants. Pharmaceuticals and personal care products, perfluorinated compounds, brominated flame retardants, and disinfection byproducts were chosen as examples to illustrate the use of this new technique in environmental analysis.