Barry E. Boyes | Authors

Articles

Modern Trends and Best Practices in Mobile-Phase Selection in Reversed-Phase Chromatography

This instalment provides an overview of the modern trends and best practices in mobile-phase selection for reversed-phase liquid chromatography (LC). In particular, we focus on selection criteria and rationales for enhancing analytical performance and ease of preparation.

Modern Trends and Best Practices in Mobile-Phase Selection in Reversed-Phase Chromatography

Modern trends in LC mobile-phase selection and preparation include using simpler mobile phases, increased use of MS-compatible mobile phases, and eliminating filtration and certain mobile-phase additives. Here, we discuss those and other trends and best practices, as well as the fundamentals behind them.