Katharina Wittmann | Authors


Light Scattering for the Masses Monoclonal Antibodies and the Preparative Use of Flow Field-Flow Fractionation (AF4)

Proteins - especially monoclonal antibodies (MABs) - have become increasingly important in pharmaceutical work. However, there are some important differences between conventional, chemically-synthesized drugs and proteins. Because of the complex and weak structure of proteins, even a slight change in conditions, such as pH value, temperature, or mechanical stress, may lead to aggregation and a loss of activity or stability.