Authors

Emma Poole
Latest Article

Switching from Helium as a Carrier Gas: Can You Afford Not To?

Switching from helium as a carrier gas is less of a problem than people think. Is it time for you to think about it?

Fotouh R. Mansour
Latest Article

The Green Component: Assessing the Environmental Impact of Analytical Methods

Green analytical chemistry (GAC) has emerged as a critical discipline focused on minimizing the environmental footprint of analytical methods. This second article in this week's series curated by Adrián Fuente-Ballesteros of the Faculty of Sciences at University of Valladolid (Spain) traces the evolution of GAC through the development of its key greenness assessment metrics.

Rajashree Chakravarti

Rajashree Chakravarti serves as the Global Product Manager for Phenomenex.

Latest Article

A Comparative Study of Various Sample Preparation Approaches for PFAS in Biofluids: A Practical Method of Biomonitoring for Anthropogenic Toxicity

Known as “forever chemicals”, PFAS exposure has been linked indirectly and directly to a range of potential health issues. The objective of this study was the development of an optimized sample preparation and LC–MS/MS method for the analysis of PFAS in serum for biomonitoring applications.

Lauren Thijs
Latest Article

MHC-Associated Peptide Proteomics (MAPPs) as a Tool for Assessment of Immunogenicity Risk Potential of Therapeutic Monoclonal Antibodies

In this study, we applied a high-sensitivity MAPPs workflow using magnetic bead-based HLA-DR/DP/DQ immunoprecipitation and high-resolution mass spectrometry (HRMS) to assess the immunogenicity risk of six marketed mAbs across a panel of 10 HLA-typed donors.

Meriem Gaida

Meriem Gaida earned her PhD in August 2023, specializing in advanced theoretical modelling and innovative data processing workflows for GC×GC–TOF-MS. She joined SepSolve in September 2023 as an applications specialist at the Peterborough demo laboratory, where she developed and demonstrated customized analytical methods for clients. In September 2024, she transitioned to LUZI AG, a fragrance house in Zurich, Switzerland, taking on the role of product safety scientist.

Latest Article

Investigating the Influence of Packaging on the Volatile Profile of Oats

In the testing of six different oat brands, headspace sorptive extraction and comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC–TOF-MS) reveal how various packaging types can affect and alter the oats’ volatile profile, underscoring the potential impact of packaging on food quality.

Cristian D'Ovidio
Latest Article

The Importance of Analytical Chemistry and Instrumental Developments for Medico-Legal and Forensic Applications

The pivotal role of analytical chemistry in the medico-legal and forensic applications is explored in this article.

Mathias Buff
Mathias Buff

Mathias Buff is with the School of Pharmaceutical Sciences and the Institute of Pharmaceutical Sciences of Western Switzerland, at the University of Geneva, in Geneva, Switzerland.


Latest Article

A Practical Excel Tool to Support the Development of Comprehensive 2D-LC Separations

An Excel-based tool has been developed to help users understand the fundamentals of comprehensive 2D-LC.

Anna Codina
Anna Codina

Anna Codina is senior director of strategy and business development at SciY. She has a distinguished academic and professional background, blending high-level scientific expertise with strategic leadership. With a background in analytical science, her interests are focused on transformative initiatives in digitization within the life sciences and the impact these transformations deliver.


Latest Article

Mastering Chromatography Method Transfer in Today’s Connected World

A look at today’s outsourcing scale, examining market dynamics around chromatography, distilling pain points and user requirements, and presenting evidence that digital, standardized method transfer can reduce risk, speed technology transfer, and improve quality, ultimately accelerating time‑to‑market.

Kurt Thaxton
Latest Article

When Home and Office Hurt Your Health

How is the indoor air affecting your health?

Marcelo Locatelli
Latest Article

White Analytical Chemistry: Balancing Performance, Sustainability, and Practicality in Modern Methods

Modern analytical science faces the critical challenge of balancing innovation and growth with environmental responsibility. White analytical chemistry (WAC) emerges as a holistic paradigm, extending beyond the eco-centric focus of green analytical chemistry (GAC) to encompass the full spectrum of analytical method development. Adrián de la Fuente-Ballesteros of the University of Valladolid (Spain) presents the first of his curated five-part series on the current trends in analytical chemistry within the framework of WAC.

Ella Sontowski
Latest Article

Mobile Phase Buffers in Liquid Chromatography: The Buffer–Detector Battle

In this installment, I primarily discuss considerations to keep in mind when choosing buffering additives that will be used for LC methods involving UV absorbance detection.

Tatiana Johnston

Tatiana Johnston is a Senior Scientist at Waters Corporation (Milford, USA).

Latest Article

Advancing Gene Therapy: Enzyme Selection for Effective RNA Oligonucleotide Mapping

New gene therapy modalities, such as CRISPR guide RNA (single guide ribonucleic acid [sgRNA]) and messenger RNA (mRNA), continue to make progress in both primate and first-in-human trials. As this progress builds, the industry remains accountable for characterizing these molecules to meet the requirements of regulatory authorities.

Miryam Perrucci
Latest Article

White Analytical Chemistry: Balancing Performance, Sustainability, and Practicality in Modern Methods

Modern analytical science faces the critical challenge of balancing innovation and growth with environmental responsibility. White analytical chemistry (WAC) emerges as a holistic paradigm, extending beyond the eco-centric focus of green analytical chemistry (GAC) to encompass the full spectrum of analytical method development. Adrián de la Fuente-Ballesteros of the University of Valladolid (Spain) presents the first of his curated five-part series on the current trends in analytical chemistry within the framework of WAC.

Marta Bevilacqua
Latest Article

HPLC 2025 Preview: Prioritization Strategies in Non-Target Screening of Environmental Samples by Chromatography with High-Resolution Mass Spectrometry

This article discusses how integrating seven prioritization strategies can enhance compound identification, support environmental risk assessment, and accelerate decision-making.

Chengqi Zheng
Yuqiao Zhang
Latest Article

Design of a 3D-Printed Needle-Plate Ion Source for High Field Asymmetric Waveform Ion Mobility Spectrometry

A new paper presents the design of a needle-plate dielectric barrier discharge DBD ion source based on 3D printing for high field asymmetric-waveform ion-mobility spectrometry (FAIMS).

Mahboubeh Lotfinia
Latest Article

The Answer’s AI. What’s the Question?

Does AI/ML help to enhance chromatographic peak integration? What do regulators say? Are you being seduced by technology?

Bruce Upbin
Latest Article

From Peaks to Patterns: AI’s Transformation of Separation Science

This article explores the current applications of artificial intelligence (AI) in chromatography. It anticipates AI’s transformative benefits for the future, looking at the impacts that separation scientists will inevitably see and are already seeing.

Elisa Jousselin
Latest Article

Method Validation for the Determination of Cocaine Derivatives in Oral Fluid Using PESI and LC–MS

The main objectives of this study were to develop a method for the measurement of cocaine derivatives in oral fluid by coupling a probe electrospray ionization (PESI) source with quadrupole time-of-flight (QTOF). The three cocaine derivatives considered were: benzoylecgonine (BZE), cocaine, and ecgonine-methylester (EME).

Peng Shang
Latest Article

Design of a 3D-Printed Needle-Plate Ion Source for High Field Asymmetric Waveform Ion Mobility Spectrometry

A new paper presents the design of a needle-plate dielectric barrier discharge DBD ion source based on 3D printing for high field asymmetric-waveform ion-mobility spectrometry (FAIMS).

Michał Młynarczyk
Latest Article

Do 3D Prints Interfere with Untargeted LC–QTOF-MS Analyses?

An investigation into whether 3D-printed sorbent devices introduce background contaminants in untargeted LC–QTOF-MS analyses.

Damien Pierret
Damien Pierret

Damien Pierret is a master’s student at the Bioengineering Faculty of Gembloux Agro-Bio Tech graduated in September 2024 with a specialization in chemsitry and bioindustries. His master’s thesis focused on the toxicological evaluation of mineral oil and his academic journey will continue by the start of a PhD in the field of mineral oil.

Ibraam Mikhail
Latest Article

HPLC 2025 Preview: On The Road With Your Chromatograph?

Brett Paull from the University of Tasmania, Tasmania and his team describe the latest development in portable LC instruments and their experience of taking portable systems out to the field.

Josephine S. Lübeck
Latest Article

HPLC 2025 Preview: Prioritization Strategies in Non-Target Screening of Environmental Samples by Chromatography with High-Resolution Mass Spectrometry

This article discusses how integrating seven prioritization strategies can enhance compound identification, support environmental risk assessment, and accelerate decision-making.

Debasmita Chakraborty
Latest Article

Two-Dimensional Liquid Chromatography Applications in Biopharmaceutical Analysis

This article reviews literature related to 2D-LC applications in the biopharmaceutical field over the past six years (2018-2024).

Bruno Stelzer
Latest Article

Wide-targeted Metabolomics in Dried Blood Spots

A high-throughput workflow for wide-targeted metabolomics in dried blood spots (DBS) is presented.

Alina Astefanei
Latest Article

Retaining Talent in Field-Flow Fractionation: An Initiative

The authors present their motivation for establishing the Young Scientists of FFF (YSFFF) initiative within the FFF community.

Zacariah L. Hildenbrand

Zacariah L. Hildenbrand is a partner of Medusa Analytical. He sits on the scientific advisory board of the Collaborative Laboratories for Environmental Analysis and Remediation (CLEAR), is a director of the Curtis Mathes Corporation (OTC:TLED), and is Research Professor at the University of Texas at El Paso, USA. Hildenbrand’s research has produced more than 60 peer-reviewed scientific journal articles and textbook chapters. He is regarded as an expert in point source attribution and has participated in some of the highest profile oil and gas contamination cases across the United States.

Latest Article

The LCGC Blog: Avenues of Circumvention and Issues with Cannabis Products: Δ8-THC, THCA Flower, and Forensics Analysis

In this edition of the LCGC Blog, Zacariah Hildenbrand, Melissa Giguere, and Kevin Schug discuss the complexities of cannabis regulations, forensic testing challenges, and the risks of unregulated products in the evolving landscape of cannabis forensics.

Manuel Bauer
Manuel Bauer

Manuel Bauer is VP product management at Bruker Daltonics.


Latest Article

Revealing the Full Proteoform Landscape with the Enhanced Power of Top-down Mass Spectrometry

Top-down proteomics offers a new window into the true complexity of protein species and promises to complement, rather than replace, traditional bottom-up methods. Here, we explore these developments and what the future might hold.

Ana Jano
Latest Article

Emerging Tools for Holistic Evaluation of Analytical Methods

The RGB model, which combines red (analytical performance), green (environmental impact), and blue (practicality), is at the heart of the concept of white analytical chemistry (WAC). While this approach has helped broaden the field’s focus and offered a more balanced evaluation system, analytical science continues to move forward, and with it come new priorities that extend beyond what the RGB framework can fully reflect. This final article of this week's series on WAC curated by Adrián Fuente-Ballesteros of the University of Valladolid (Spain) presents new tools intended to fill that gap.

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