How to modernize an older pharmaceutical monograph from an HPLC column to an UHPLC column, along with calculated time and solvent savings.
Kenneth Berthelette
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Kenneth Berthelette works as a senior scientist in the Consumables and Lab Automation Group of Waters Corporation where he focuses on marketing support and collateral generation. Ken’s areas of expertise include reversed‑phase LC method development and troubleshooting and HILIC method development.
Articles by Kenneth Berthelette
A novel surface modification technology has been developed to reduce interactions between analytes and metal surfaces in HPLC instruments and columns. We demonstrate the impact of this technology on peak symmetry, peak area, and injection-to-injection and column-to-column reproducibility for several metal-sensitive analytes.
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Latest Updated Articles
Modifying the Metal Surfaces in HPLC Systems and Columns to Prevent Analyte Adsorption and Other Deleterious EffectsPublished: June 1st 2022 | Updated:
Future-Proofing Validated Pharmacopeia Methods: A Case Study of Improving Throughput and Decreasing Operational CostPublished: July 10th 2023 | Updated:
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