Kristopher A. Barnthouse

home / authors / kristopher-a-barnthouse

Articles

Ion-Exchange Displacement Chromatography: Scale-Up and Displacer Clearance for Recombinant Human Brain-Derived Neurotrophic Factor

Ion-Exchange Displacement Chromatography: Scale-Up and Displacer Clearance for Recombinant Human Brain-Derived Neurotrophic Factor

Kristopher A. Barnthouse;William Trompeter;Rodrick Jones;Randall Rupp;Steven M. Cramer
November 1st 1999

Displacement chromatography is a viable alternative to elution chromatography, but the biotechnology industry has yet to fully exploit this technique. The authors present results of a pilot-scale ion-exchange displacement process developed for the removal of variants from recombitant human brain-derived neutrotrophic factor.

Latest Updated Articles

Technology Trends in Separation Science: Data Handling
Published: July 3rd 2024 | Updated: July 8th 2024
Technology Trends in Separation Science: Data Handling
Human monoclonal antibody to fight cancer | Image Credit: © Yuriy - stock.adobe.com
Published: June 28th 2024 | Updated: October 26th 2024
Analysis of Therapeutic Monoclonal Antibodies Using a Platform Size Exclusion-HPLC Method
Virus protection. Vaccine search. Antibodies and viral infection. Immune defense of the body. Attack on antigens 3D illustration By Siarhei - stock.adobe.com
Published: July 16th 2024 | Updated: October 26th 2024
Characterization of Product Related Variants in Therapeutic Monoclonal Antibodies
Chromatograph with glass sample bottles | Image Credit: © JJIMAGE - stock.adobe.com
Published: September 10th 2024 | Updated: October 26th 2024
Analytical Method Lifecycle of SFC Methods from Development Use to Routine QC Implementation; Supporting Small Molecule R&D and Commercialization
Glass vial, pipette and woman scientist in laboratory for medical study, research or experiment. Test tube, dropper and professional female person with chemical liquid for pharmaceutical innovation. | Image Credit: © peopleimages.com - stock.adobe.com
Published: September 16th 2024 | Updated: October 26th 2024
Are You Sure You Understand USP <621>?
Scientist moved the vial of sample out from the tray autosampler of the Liquid Chromatography Mass Spectrometer LC/MS after the analysis was complete. | Image Credit: © S. Singha - stock.adobe.com
Published: September 13th 2024 | Updated: October 26th 2024
In-Loop Analyte Degradation in Two-Dimensional Liquid Chromatography: Example and Solutions