|Articles|November 1, 1999
- November 1999
- Volume 17
- Issue 11
- Pages: 1028–1035
Ion-Exchange Displacement Chromatography: Scale-Up and Displacer Clearance for Recombinant Human Brain-Derived Neurotrophic Factor
Displacement chromatography is a viable alternative to elution chromatography, but the biotechnology industry has yet to fully exploit this technique. The authors present results of a pilot-scale ion-exchange displacement process developed for the removal of variants from recombitant human brain-derived neutrotrophic factor.
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Because of toxicity concerns and a lack of relevant case studies, displacement chromatography has yet to be embraced by the biotechnology industry. This article is an example of a protein displacement process used at the pilot scale.
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A Coin-Toss Experiment, Part II – Limits of the Analogyabout 26 years ago
Readers' Question – Carryover, Mobile-Phase Temperature, and Column Careabout 26 years ago
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