Ion-Exchange Displacement Chromatography: Scale-Up and Displacer Clearance for Recombinant Human Brain-Derived Neurotrophic Factor

Publication
Article
LCGC North AmericaNovember 1999
Volume 17
Issue 11
Pages: 1028–1035

Because of toxicity concerns and a lack of relevant case studies, displacement chromatography has yet to be embraced by the biotechnology industry. This article is an example of a protein displacement process used at the pilot scale.

LCGC 17(11), 1028–1035 (1999).
Articles in this issue
Monoliths as Stationary Phases for Separating Biopolymers – Fourth-Generation Chromatography Sorbents
Monoliths as Stationary Phases for Separating Biopolymers – Fourth-Generation Chromatography Sorbents
Automated DNA Fragment Analysis by High Performance Ultrathin-Layer Agarose Gel Electrophoresis
Automated DNA Fragment Analysis by High Performance Ultrathin-Layer Agarose Gel Electrophoresis
A Coin-Toss Experiment, Part II – Limits of the Analogy
A Coin-Toss Experiment, Part II – Limits of the Analogy
Ion-Exchange Displacement Chromatography: Scale-Up and Displacer Clearance for Recombinant Human Brain-Derived Neurotrophic Factor
Ion-Exchange Displacement Chromatography: Scale-Up and Displacer Clearance for Recombinant Human Brain-Derived Neurotrophic Factor
wrench and gear
Readers' Question – Carryover, Mobile-Phase Temperature, and Column Care
Cleaning Validation
Cleaning Validation
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