Ion-Exchange Displacement Chromatography: Scale-Up and Displacer Clearance for Recombinant Human Brain-Derived Neurotrophic Factor

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LCGC North America, November 1999, Volume 17, Issue 11
Pages: 1028–1035

Because of toxicity concerns and a lack of relevant case studies, displacement chromatography has yet to be embraced by the biotechnology industry. This article is an example of a protein displacement process used at the pilot scale.