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Michael Mølhøj

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Articles

Figure1.jpg

Monitoring of On-column Methionine Oxidation as Part of a System Suitability Test During UHPLC–MS/MS Peptide Mapping

Björn Mautz;Maximiliane König;Vincent Larraillet;Michael Mølhøj
November 1st 2019

Long-term column use can lead to on-column methionine oxidation during LC–MS/MS peptide mapping of antibody-based biotherapeutics. Following the approach described here minimizes the risk of measuring oxidative artifacts, and helps generate high quality data to provide reliable quantitative information about product-related heterogeneities.

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