Porvair Sciences

Evaporation enhances method sensitivity. This study investigates the impact of gas temperature and flow rate on blowdown evaporation of solvents and their mixtures

Solid Phase Extraction (SPE) is vital for chromatographic analysis. However, traditional loose-packed SPE products struggle with channelling and inconsistent resin mass, resulting in poor recovery and reproducibility. Discover how innovative composite technology overcomes these challenges to transform sample preparation, ensuring reliable and sensitive chromatographic data.

For many years, Solid Phase Extraction (SPE) has been performed using plates and cartridges packed with a bed of loose media. Extracting samples of interest while removing contamination from samples presented to the chromatography system results in lower costs associated with detector maintenance and extends column lifespan. Cleaner samples also improve specificity in analysis and increase sensitivity. Traditional products, however, have inherent limitations in reproducibility of flow and recovery. The innovative composite technology found in the Microlute® range greatly improves flow consistency providing a step change in the reproducibility of processing and analyte recover.

The Microlute® CSi products use a novel composite technology which uses a blend of porous plastic and chromatographic SPE resin. This technology has been designed to eliminate issues caused by inherent issues and inconsistent packing of loose packed SPE plates. The data in this application note compares SPE results from a C18 10 mg loose packed plate with a C18 10 mg composite plate (Microlute® CSi) which were both created using the same batch of C18 resin.

This application note demonstrates a novel composite technology that enhances reproducibility of solid phase extraction compared to a traditional loose packed format.

Porvair Sciences Ultraseal™ LITE is the effortless, lightweight heat sealer designed to tightly seal polypropylene, polyethylene and polystyrene microplates and glass tube.

Solid Phase Extraction (SPE) is so reliable…said no one ever! Although there are many tips, tricks and recommendations to overcome common challenges with SPE, one solution lies within the structure of products used to carry out this method. In this episode of LCGC’s Dedicated Dialogue, James Edwards from Porvair Sciences introduces SPE, its evolution and its future with insights from a manufacturing and product development perspective on SPE for sample preparation workflows can be improved and make life easier in the lab for researchers.

James Edwards, an Application Scientist and Chromatographer at Porvair Sciences, discusses the challenges and advancements in solid-phase extraction (SPE) as a sample preparation technique for chromatography.

This application note provides insight into how solvents can be efficiently dried down using a nitrogen blowdown evaporator and a guide on the best place to start.

Advantages of using a supported liquid extraction (SLE) over liquid–liquid extraction (LLE) method for extracting a range of analytes from pig plasma.

This application notes introduces an SPE LC–MS/MS methodology using the Microlute™ CP SCX SPE 96-well microplate for the determination of 12 opioids from human urine.

This application note demonstrates the robust SPE LC–MS methodology of the Microlute® CP Reverse Phase SPE 30 mg plates on a range of neutral, acidic, and basic analytes.

The 30 mg Microlute® CP Strong Cation Exchange (SCX) 96 well plate compares performance in recoveries and reproducibility against five competitor loose-filled 30 mg SCX products.

This short application note demonstrates the effectiveness of the Microlute™ Protein Precipitation Plate for the removal of proteins.