Robert MacNeill is Head of Method Development at LabCorp Drug Development. He received his bachelor’s degree with honours in chemistry from Heriot-Watt University, and his M.Sc. in analytical chemistry from the University of Huddersfield, UK. Robert is also a Chartered Chemist and Fellow of the Royal Society of Chemistry, and has 24 years of experience in all aspects of quantitative bioanalytical LC–MS method development—with 15 of these spent heading method development activities within LabCorp Drug Development at the Somerset (New Jersey, USA) site. Taking a prominent role in innovation projects with related R&D activities, Robert has been an active contributor to the scientific literature for many years.
A novel approach using hydrophilic-phase extraction (HPE) for the analysis of oligonucleotides in bioanalysis applications is described. The HPE method was proven to be a critical part of a fully quantitative HILIC–high-resolution mass spectrometry (HRMS) method for the RNA oligonucleotide and has potential for general application.