CONTINUE TO SITE

OR WAIT null SECS

SIFT-MS: Real-Time Volatiles Analysis for Continuous Manufacturing of Pharmaceuticals Automated Sample Prep in Regulated and Nonregulated Labs Just Got Easier Trends in Modern LC Separation Workflows Strategies for Improving Peak Tailing The Evolution of Breath Analysis

SIFT-MS: Real-Time Volatiles Analysis for Continuous Manufacturing of PharmaceuticalsAutomated Sample Prep in Regulated and Nonregulated Labs Just Got EasierTrends in Modern LC Separation WorkflowsStrategies for Improving Peak TailingThe Evolution of Breath Analysis

Topics

View More Liquid Chromatography (LC/HPLC)Gas Chromatography (GC)Sample Preparation Mass Spectrometry Pharmaceutical Analysis Environmental Analysis Food and Beverage Analysis

Liquid Chromatography (LC/HPLC)Gas Chromatography (GC)Sample PreparationMass SpectrometryPharmaceutical AnalysisEnvironmental AnalysisFood and Beverage Analysis

Publications

All Publications LCGC North America LCGC Europe LCGC Asia Pacific LCGC Supplements The Column E-Books The Application Notebook

All PublicationsLCGC North AmericaLCGC EuropeLCGC Asia PacificLCGC SupplementsThe ColumnE-BooksThe Application Notebook

All NewsInterviews

All App Notes Biological, Medical, and Clinical Biopharmaceuticals Cannabis Chiral Environmental Food and Beverage GC GC-MS General Industrial LC LC-MS Medical/Biological Misc Techniques Pharmaceuticals Polymers Sample Prep Size-Exclusion Chromatography (SEC)Supercritical Fluid Chromatography (SFC)

All App NotesBiological, Medical, and ClinicalBiopharmaceuticalsCannabisChiralEnvironmentalFood and BeverageGCGC-MSGeneralIndustrialLCLC-MSMedical/BiologicalMisc TechniquesPharmaceuticalsPolymersSample PrepSize-Exclusion Chromatography (SEC)Supercritical Fluid Chromatography (SFC)

Conferences

Conference Coverage Conference Listing

Webcasts

Resources

Products E-Books ChromTube Events Analytically Speaking Podcast Podcasts Podcast Series Sponsored Videos Q&As Sponsored Content Content Engagement Hubs Tips & Tricks Industry Insights Career Opportunities

ProductsE-BooksChromTubeEventsAnalytically Speaking PodcastPodcastsPodcast SeriesSponsored VideosQ&AsSponsored ContentContent Engagement HubsTips & TricksIndustry InsightsCareer Opportunities

Rod McIlwrick | Authors

home

Articles

The Application Notebook

Improved LC–MS Performance — A Three-Step Method for Minimizing Background Signals and Increasing Ionization Efficiency

One problem frequently encountered in LC–MS is the appearance of mass peaks, which appear totally unrelated to the samples run - "ghost" mass peaks. It is impossible to differentiate whether these signals come from an unknown component in the sample co-eluting with a known peak, or from an impurity in the mobile phase or from some residual contamination "bleeding" from the column.