Analysis of Secondary Metabolites from Myxobacteria using ESI-TOF–MS and PCA
The exploration of myxobacterial metabolite profiles by LC–MS screening for the presence of new natural products is described. Extracts from fermentations of Myxococcus strains are analysed by UPLC-coupled ESI-TOF mass spectrometry and the obtained data are processed using principal component analysis (PCA). The generation of molecular formulae from accurate mass measurements facilitates rapid compound identification.
Daniel Krug, Gabriela Zurek, Birgit Schneider, Carsten Bässmann and Rolf Müller, Bruker Daltonik
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